ArticleCerebral cortex (New York, N.Y. : 1991)2013
Intrinsic electrophysiology of mouse corticospinal neurons: a class-specific triad of spike-related properties.
Article in Cerebral cortex (New York, N.Y. : 1991), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Modeling sources of interlaboratory variability in electrophysiological properties of mammalian neurons.Journal of neurophysiology · 2018Pooled it
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- Progressive noradrenergic degeneration and motor cortical dysfunction in Parkinson's disease.Acta pharmacologica Sinica · 2025Review
- Motor cortical neuronal hyperexcitability associated with α-synuclein aggregation.NPJ Parkinson's disease · 2025Article
- Self-organized and self-sustained ensemble activity patterns in simulation of mouse primary motor cortex.bioRxiv : the preprint server for biology · 2025Article
- Dopamine neuron degeneration in the Ventral Tegmental Area causes hippocampal hyperexcitability in experimental Alzheimer's Disease.Molecular psychiatry · 2024Article
- Variation and convergence in the morpho-functional properties of the mammalian neocortex.Frontiers in systems neuroscience · 2024Review
- Data-driven multiscale model of macaque auditory thalamocortical circuits reproduces in vivo dynamics.Cell reports · 2023Article
- Reduced thalamic excitation to motor cortical pyramidal tract neurons in parkinsonism.Science advances · 2023Article
- Multiscale model of primary motor cortex circuits predicts in vivo cell-type-specific, behavioral state-dependent dynamics.Cell reports · 2023Article
- Motor cortex analogue neurons in songbirds utilize Kv3 channels to generate ultranarrow spikes.eLife · 2023Article
- Unique molecular features and cellular responses differentiate two populations of motor cortical layer 5b neurons in a preclinical model of ALS.Cell reports · 2022Article
- Kv2.1 Potassium Channels Regulate Repetitive Burst Firing in Extratelencephalic Neocortical Pyramidal Neurons.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Sphingosine-1-phosphate receptor 1 agonist SEW2871 alters membrane properties of late-firing somatostatin expressing neurons in the central lateral amygdala.Neuropharmacology · 2022Article
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4 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
Corticospinal pyramidal neurons mediate diverse aspects of motor behavior. We measured spike-related electrophysiological properties of identified corticospinal neurons in primary motor cortex slices from young adult mice. Several consistent features were observed in the suprathreshold responses to current steps: 1) Corticospinal neurons fired relatively fast action potentials (APs; width at half-maximum 0.65 ± 0.13 ms, mean ± standard deviation [SD]) compared with neighboring callosally projecting corticostriatal neurons. Corticospinal AP width was intermediate between 2 classes of inhibitory interneuron in layer 5B. Spike-to-spike variability in AP width and other spike waveform parameters was low, even during repetitive firing up to 20 Hz, that is, the relative narrowness of corticospinal APs was essentially frequency independent. 2) Frequency-current (f-I) relationships were nearly linear. 3) Trains of APs displayed regular firing, with rates typically staying constant or accelerating over time. Corticospinal neurons recorded from older mice (up to 4 months) or from a separate lateral cortical area (Region B; corresponding to secondary somatosensory cortex) showed generally similar intrinsic properties. Our findings have implications for interpreting spike waveforms of in vivo recorded neurons in the motor cortex. This analysis provides a framework for further biophysical and computational investigations of corticospinal neurons and their roles in motor cortical function.
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