ArticleClinical and vaccine immunology : CVI2012
Lipopolysaccharide heterogeneity in the atypical group of novel emerging Brucella species.
Article in Clinical and vaccine immunology : CVI, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Brucella microti and Rodent-Borne Brucellosis: A Neglected Public Health Threat.Zoonoses and public health · 2025Review
- TheAnnual review of microbiology · 2023Review
- The Retrospective on AtypicalMicroorganisms · 2022Review
- Uncovering the Hidden Credentials ofMicrobiology and molecular biology reviews : MMBR · 2021Review
- When the Going Gets Rough: The Significance ofFrontiers in microbiology · 2021Review
- Development of an Immunodiagnostic Test for Screening Human Brucellosis Cases Using the Whole-Cell Antigens of Brucella abortus.The Malaysian journal of medical sciences : MJMS · 2020Article
- The Role of the Flagellar Protein FlgJ in the Virulence ofFrontiers in cellular and infection microbiology · 2020Article
- Omp2b Porin Alteration in the Course of Evolution ofFrontiers in microbiology · 2020Article
- Lethality ofVirulence · 2019Article
- Localized incorporation of outer membrane components in the pathogenThe EMBO journal · 2019Article
- Genetic and Phenotypic Characterization of the Etiological Agent of Canine Orchiepididymitis SmoothFrontiers in veterinary science · 2019Article
- Phenotypic and Molecular Characterization ofFrontiers in veterinary science · 2018Article
- The Fast-GrowingFrontiers in microbiology · 2018Article
- WadD, a NewFrontiers in microbiology · 2018Article
- Brucella spp. of amphibians comprise genomically diverse motile strains competent for replication in macrophages and survival in mammalian hosts.Scientific reports · 2017Article
- Transcriptome-Wide Identification of Hfq-Associated RNAs in Brucella suis by Deep Sequencing.Journal of bacteriology · 2016Article
- Toll-Like Receptors 2 and 4 Cooperate in the Control of the Emerging PathogenFrontiers in cellular and infection microbiology · 2016Article
- AFrontiers in cellular and infection microbiology · 2016Article
- Development of a bead-based Luminex assay using lipopolysaccharide specific monoclonal antibodies to detect biological threats from Brucella species.BMC microbiology · 2015Article
- Smooth to Rough Dissociation in Brucella: The Missing Link to Virulence.Frontiers in cellular and infection microbiology · 2015Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, novel Brucella strains with phenotypic characteristics that were atypical for strains belonging to the genus Brucella have been reported. Phenotypically many of these strains were initially misidentified as Ochrobactrum spp. Two novel species have been described so far for these strains, i.e., B. microti and B. inopinata, and other strains genetically related to B. inopinata may constitute other novel species as well. In this study, we analyzed the lipopolysaccharides (LPS) (smooth LPS [S-LPS] and rough LPS [R-LPS]) of these atypical strains using different methods and a panel of monoclonal antibodies (MAbs) directed against several epitopes of the Brucella O-polysaccharide (O-PS) and R-LPS. Among the most striking results, Brucella sp. strain BO2, isolated from a patient with chronic destructive pneumonia, showed a completely distinct S-LPS profile in silver stain gels that looked more similar to that of enterobacterial S-LPS. This strain also failed to react with MAbs against Brucella O-PS epitopes and showed weak reactivity with anti-R-LPS MAbs. B. inopinata reference strain BO1 displayed an M-dominant S-LPS type with some heterogeneity relative to the classical M-dominant Brucella S-LPS type. Australian wild rodent strains belonging also to the B. inopinata group showed a classical A-dominant S-LPS but lacked the O-PS common (C) epitopes, as previously reported for B. suis biovar 2 strains. Interestingly, some strains also failed to react with anti-R-LPS MAbs, such as the B. microti reference strain and B. inopinata BO1, suggesting modifications in the core-lipid A moieties of these strains. These results have several implications for serological typing and serological diagnosis and underline the need for novel tools for detection and correct identification of such novel emerging Brucella spp.
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