ArticleAmerican journal of physiology. Endocrinology and metabolism2012
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.
Article in American journal of physiology. Endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- CCK-sensitive C fibers activate NTS leptin receptor-expressing neurons via NMDA receptors.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Low-dose peripheral leptin infusion produces selective activation of ventromedial hypothalamic and hindbrain STAT3.American journal of physiology. Endocrinology and metabolism · 2023Article
- Olanzapine Administration Reduces Chemotherapy-Induced Nausea Behavior in Rats.Biological research for nursing · 2021Article
- Leptin Sensitizes NTS Neurons to Vagal Input by Increasing Postsynaptic NMDA Receptor Currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Leptin receptor-expressing nucleus tractus solitarius neurons suppress food intake independently of GLP1 in mice.JCI insight · 2020Article
- Inferring Regulatory Programs Governing Region Specificity of Neuroepithelial Stem Cells during Early Hindbrain and Spinal Cord Development.Cell systems · 2019Article
- Role of PTP1B in POMC neurons during chronic high-fat diet: sex differences in regulation of liver lipids and glucose tolerance.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Low-dose leptin infusion in the fourth ventricle of rats enhances the response to third-ventricle leptin injection.American journal of physiology. Endocrinology and metabolism · 2017Article
- Article
- The effect of leptin replacement on sleep-disordered breathing in the leptin-deficient ob/ob mouse.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis.Molecular metabolism · 2015Article
- Protein-tyrosine phosphatase 1B (PTP1B) is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) signaling.The Journal of biological chemistry · 2014Article
- Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor.Molecular metabolism · 2014Article
- Relationship status update for PTP1B and LepR: It׳s complicated.Molecular metabolism · 2014Article
- Metabolic regulation by protein tyrosine phosphatases.Journal of biomedical research · 2014Article
- Melanocortin signaling in the brainstem influences vagal outflow to the stomach.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Central regulation of metabolism by protein tyrosine phosphatases.Frontiers in neuroscience · 2012Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Leptin regulates energy balance through central circuits that control food intake and energy expenditure, including proopiomelanocortin (POMC) neurons. POMC neuron-specific deletion of protein tyrosine phosphatase 1B (PTP1B) (Ptpn1(loxP/loxP) POMC-Cre), a negative regulator of CNS leptin signaling, results in resistance to diet-induced obesity and improved peripheral leptin sensitivity in mice, thus establishing PTP1B as an important component of POMC neuron regulation of energy balance. POMC neurons are expressed in the pituitary, the arcuate nucleus of the hypothalamus (ARH), and the nucleus of the solitary tract (NTS) in the hindbrain, and it is unknown how each population might contribute to the phenotype of POMC-Ptp1b(-/-) mice. It is also unknown whether improved leptin sensitivity in POMC-Ptp1b(-/-) mice involves altered melanocortin receptor signaling. Therefore, we examined the effects of hindbrain administration (4th ventricle) of leptin (1.5, 3, and 6 μg) or the melanocortin 3/4R agonist melanotan II (0.1 and 0.2 nmol) in POMC-Ptp1b(-/-) (KO) and control PTP1B(fl/fl) (WT) mice on food intake, body weight, spontaneous physical activity (SPA), and core temperature (T(C)). The results show that KO mice were hypersensitive to hindbrain leptin- and MTII-induced food intake and body weight suppression and SPA compared with WT mice. Greater increases in leptin- but not MTII-induced T(C) were also observed in KO vs. WT animals. In addition, KO mice displayed elevated hindbrain and hypothalamic MC4R mRNA expression. These studies are the first to show that hindbrain administration of leptin or a melanocortin receptor agonist alters energy balance in mice likely via participation of hindbrain POMC neurons.
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