ArticleNature communications2012
ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 133 papers.
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Who cites it
133 citing papers in PubMed, 269 citations in OpenAlex.
- Brassinosteroid signaling regulates PIN5/10-mediated intracellular auxin homeostasis to promote lateral root development in tomato.Plant communications · 2026Article
- The ZmMIR319A-ZmTCP5/44 module bifurcates into two pathways to coordinately regulate leaf angle and thermotolerance in maize.Plant communications · 2026Article
- Metabolism meets transport: a new perspective on auxin homeostasis at subcellular level.Planta · 2026Review
- Tailored for swift recognition: A structural perspective on secondary active plant hormone transporters.The Plant journal : for cell and molecular biology · 2026Review
- Illuminating the subcellular maze: fluorescence-activated organelle sorting in plant sciences.Journal of experimental botany · 2025Review
- Tomato pollen tube growth requires flavonol glycosylation.Plant physiology · 2025Article
- Mechanisms of auxin action in plant growth and development.Nature reviews. Molecular cell biology · 2025Review
- Rice Heat Stress Response: Physiological Changes and Molecular Regulatory Network Research Progress.Plants (Basel, Switzerland) · 2025Review
- ThePlants (Basel, Switzerland) · 2025Article
- Biosynthesis and Physiological Significance of Organ-Specific Flavonol Glycosides in Solanaceae.bioRxiv : the preprint server for biology · 2025Article
- Over 25 years of decrypting PIN-mediated plant development.Nature communications · 2024Review
- Mapping the membrane orientation of auxin homeostasis regulators PIN5 and PIN8 in Arabidopsis thaliana root cells reveals their divergent topology.Plant methods · 2024Article
- PfPIN5 promotes style elongation by regulating cell length in Primula forbesii Franch.Annals of botany · 2024Article
- Auxin efflux carrier PsPIN4 identified through genome-wide analysis as vital factor of petal abscission.Frontiers in plant science · 2024Article
- Genome-wide investigation of ABCB, PIN, and AUX/LAX gene families and their involvement in the formation of leaf protrusions inFrontiers in plant science · 2024Article
- Auxin and abiotic stress responses.Journal of experimental botany · 2023Review
- Substrate recognition and transport mechanism of the PIN-FORMED auxin exporters.Trends in biochemical sciences · 2023Review
- Genome-wide analysis of PIN genes in cultivated peanuts (Arachis hypogaea L.): identification, subcellular localization, evolution, and expression patterns.BMC genomics · 2023Article
- Article
- Integrating stay-green and PIN-FORMED genes: PIN-FORMED genes as potential targets for designing climate-resilient cereal ideotypes.AoB PLANTS · 2023Review
73 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
21 authors at 9 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Auxin is a key coordinative signal required for many aspects of plant development and its levels are controlled by auxin metabolism and intercellular auxin transport. Here we find that a member of PIN auxin transporter family, PIN8 is expressed in male gametophyte of Arabidopsis thaliana and has a crucial role in pollen development and functionality. Ectopic expression in sporophytic tissues establishes a role of PIN8 in regulating auxin homoeostasis and metabolism. PIN8 co-localizes with PIN5 to the endoplasmic reticulum (ER) where it acts as an auxin transporter. Genetic analyses reveal an antagonistic action of PIN5 and PIN8 in the regulation of intracellular auxin homoeostasis and gametophyte as well as sporophyte development. Our results reveal a role of the auxin transport in male gametophyte development in which the distinct actions of ER-localized PIN transporters regulate cellular auxin homoeostasis and maintain the auxin levels optimal for pollen development and pollen tube growth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.