Evidence map›Paper›PMID 22760564›Full record

Trial reportThe American journal of clinical nutrition2012

Vitamin D, tuberculin skin test conversion, and latent tuberculosis in Mongolian school-age children: a randomized, double-blind, placebo-controlled feasibility trial.

Davaasambuu Ganmaa, Edward Giovannucci, Barry R Bloom, Wafaie Fawzi, Winthrop Burr, Dulguun Batbaatar, Nyamjav Sumberzul, Michael F Holick, Walter C Willett

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01244204 (Vitamin D Supplementations as Adjunct to Anti-tuberculosis Drugs in Mongolia), which is not on this map. Cited by 54 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 10 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01244204 nacompletednot on this map

Vitamin D Supplementations as Adjunct to Anti-tuberculosis Drugs in Mongolia

TypeinterventionalSponsorHarvard School of Public Health (HSPH)Ran2009 to 2011Enrolled120ConditionsVitamin D Deficiency, TuberculosisArmsVitamin D, Placebo
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 10 syntheses or guidelines pooled it, 118 citations in OpenAlex.

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  14. Daily adjunctive therapy with vitamin DJournal of internal medicine · 2018
    Trial
  15. Efficacy of vitamin DTrials · 2017
    Trial
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Davaasambuu GanmaaDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA. gdavaasa@hsph.harvard.edu
Edward Giovannucci
Barry R Bloom
Wafaie Fawzi
Winthrop Burr
Dulguun Batbaatar
Nyamjav Sumberzul
Michael F Holick
Walter C Willett
Harvard University · US

Funding

Vitamin D supplementations as adjunct to anti-tuberculosis drugs in MongoliaR00HL089710 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI DAVAASAMBUU, GANMAA · 2011 to 2013
$679k
Vitamin D supplementations as adjunct to anti-tuberculosis drugs in MongoliaK99HL089710 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI DAVAASAMBUU, GANMAA · 2008 to 2009
$213k
NHLBI NIH HHS 4 R00 HL089710-03NHLBI NIH HHS 5 K99 HL089710-02NHLBI NIH HHS K99 HL089710
6 · The paper itself

Abstract

backgroundBy modulating immune function, vitamin D might increase innate immunity and inhibit the growth of initial bacterial invasion and protect against tuberculosis infection.

objectiveWe examined the effect of vitamin D supplementation on tuberculin skin test (TST) conversion.

designA double-blind, placebo-controlled study was conducted in 120 Mongol schoolchildren. We estimated the prevalence of latent tuberculosis infection at baseline and examined the effect of vitamin D (800 IU/d) on serum concentrations of 25-hydroxyvitamin D [25(OH)D] and TST conversion.

resultsAt baseline, the mean (±SD) 25(OH)D concentration was 7 ± 4 ng/mL, and all concentrations were <20 ng/mL. Vitamin D supplementation increased serum 25(OH)D by a mean of 12.7 ng/mL compared with placebo (P < 0.0001). At baseline, 16 children in the vitamin D group and 18 in the placebo group were TST positive (P = 0.7). Over 6 mo, TSTs converted to positive in 5 (11%) children receiving vitamin D compared with 11 (27%) receiving placebo (RR: 0.41; 95% CI: 0.16, 1.09; P = 0.06). Only one TST conversion occurred among those whose serum 25(OH)D concentration increased to >20 ng/mL, whereas 8 TST conversions occurred in those whose final 25(OH)D concentration remained <10 ng/mL (P = 0.05). The mean increase in stature was 2.9 ± 1.6 cm in the vitamin D group and 2.0 ± 1.7 cm in the placebo group (95% CI: 2.16, 2.81; P < 0.003).

conclusionsVitamin D supplementation for 6 mo had significant favorable effects on serum 25(OH)D concentrations and on growth in stature. A trend was seen toward fewer TST conversions in the vitamin D group. This trial was registered at clinicaltrials.gov as NCT01244204.

Indexed as

Dietary SupplementsAdolescentChildDose-Response Relationship, DrugDouble-Blind MethodFeasibility StudiesFemaleHumansLatent TuberculosisMaleMongoliaTuberculin TestVitamin DVitamin D

Identifiers

PMID22760564
PMCPMC3396446
OpenAlexW2148828640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.