ArticleTranslational psychiatry2012
The influence of polygenic risk for bipolar disorder on neural activation assessed using fMRI.
Article in Translational psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of associations between functional MRI activity and polygenic risk for schizophrenia and bipolar disorder.Brain imaging and behavior · 2019Pooled it
- Article
- Recent developments in imaging transcriptomics for psychiatric disorders.Psychoradiology · 2026Review
- Association between polygenic risk for Alzheimer's disease and brain structure in children and adults.Alzheimer's research & therapy · 2023Article
- Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives.Neuropsychiatric disease and treatment · 2023Review
- Genetic and environment effects on structural neuroimaging endophenotype for bipolar disorder: a novel molecular approach.Translational psychiatry · 2022Article
- Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder.Brain sciences · 2021Article
- Multimodal hippocampal and amygdala subfield volumetry in polygenic risk for Alzheimer's disease.Neurobiology of aging · 2021Article
- White Matter Microstructure and Its Relation to Longitudinal Measures of Depressive Symptoms in Mid- and Late Life.Biological psychiatry · 2019Article
- The Translational Potential of Neuroimaging Genomic Analyses To Diagnosis And Treatment In The Mental Disorders.Proceedings of the IEEE. Institute of Electrical and Electronics Engineers · 2019Article
- Polygenic risk score analyses of symptoms and treatment response in an antipsychotic-naive first episode of psychosis cohort.Translational psychiatry · 2018Article
- Replication in Imaging Genetics: The Case of Threat-Related Amygdala Reactivity.Biological psychiatry · 2018Review
- Polygenic risk score: use in migraine research.The journal of headache and pain · 2018Review
- A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Article
- Genome-wide association study of subcortical brain volume in PTSD cases and trauma-exposed controls.Translational psychiatry · 2017Article
- Genetic tests in major psychiatric disorders-integrating molecular medicine with clinical psychiatry-why is it so difficult?Translational psychiatry · 2017Review
- MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls.Translational psychiatry · 2017Article
- Multimodal Brain Imaging Reveals Structural Differences in Alzheimer's Disease Polygenic Risk Carriers: A Study in Healthy Young Adults.Biological psychiatry · 2017Article
- Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations.NeuroImage. Clinical · 2017Article
- Identification of Susceptible Loci and Enriched Pathways for Bipolar II Disorder Using Genome-Wide Association Studies.The international journal of neuropsychopharmacology · 2016Article
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Authors and funding
10 authors.
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Abstract
Genome-wide association studies (GWAS) have demonstrated a significant polygenic contribution to bipolar disorder (BD) where disease risk is determined by the summation of many alleles of small individual magnitude. Modelling polygenic risk scores may be a powerful way of identifying disrupted brain regions whose genetic architecture is related to that of BD. We determined the extent to which common genetic variation underlying risk to BD affected neural activation during an executive processing/language task in individuals at familial risk of BD and healthy controls. Polygenic risk scores were calculated for each individual based on GWAS data from the Psychiatric GWAS Consortium Bipolar Disorder Working Group (PGC-BD) of over 16 000 subjects. The familial group had a significantly higher polygene score than the control group (P=0.04). There were no significant group by polygene interaction effects in terms of association with brain activation. However, we did find that an increasing polygenic risk allele load for BD was associated with increased activation in limbic regions previously implicated in BD, including the anterior cingulate cortex and amygdala, across both groups. The findings suggest that this novel polygenic approach to examine brain-imaging data may be a useful means of identifying genetically mediated traits mechanistically linked to the aetiology of BD.
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