ArticleJournal of materials science. Materials in medicine2012
Ketoprofen-liposomes formulation for clinical therapy.
Article in Journal of materials science. Materials in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Chitosan Soft Matter Vesicles Loaded with Acetaminophen as Promising Systems for Modified Drug Release.Molecules (Basel, Switzerland) · 2023Article
- Bioactive Collagen Hydrolysate-Chitosan/Essential Oil Electrospun Nanofibers Designed for Medical Wound Dressings.Pharmaceutics · 2021Article
- Assessment of the In Vivo Release and Biocompatibility of Novel Vesicles Containing Zinc in Rats.Molecules (Basel, Switzerland) · 2021Article
- Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats.Polymers · 2021Article
- Evaluation of Antinociceptive Effects of Chitosan-Coated Liposomes Entrapping the Selective Kappa Opioid Receptor Agonist U50,488 in Mice.Medicina (Kaunas, Lithuania) · 2021Article
- In Vivo Assessment of Thermosensitive Liposomes for the Treatment of Port Wine Stains by Antifibrinolytic Site-Specific Pharmaco-Laser Therapy.Pharmaceutics · 2020Article
- The use of lipid-based nanocarriers for targeted pain therapies.Frontiers in pharmacology · 2013Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipid (L-α-phosphatidylcholine) was used in liposome-ketoprofen formulation to obtain vesicles systems characterized by a net positive charge along the liposomal surface. A careful analysis of vesicles formation and systems stability was made. Dynamic stability and specificity of liposomes disruption and prolonged release of ketoprofen was provided by steric effect accomplished on the vesicle surface by chitosan molecules, which were introduced into the system additionally. The retardation effect of the liposomes containing ketoprofen was tested in vitro and in vivo. The studies have shown that the liposomes containing ketoprofen obtained are characterized by a net positive charge and an average diameter of 1,287 nm for dialyzed solutions (pH 7.40). This formulation presents in vivo significant antinociceptive effects starting at 90 min, with a maximum intensity between 2 and 8 h, prolonged more than 10 h, and an analgesic activity within 3-4 h.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.