ArticleEuropean radiology2012
Spectral CT of carotid atherosclerotic plaque: comparison with histology.
Article in European radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 68 citations in OpenAlex.
- Photon-Counting Computed Tomography in Atherosclerotic Plaque Characterization.Diagnostics (Basel, Switzerland) · 2024Review
- Development of physiologically-informed computational coronary artery plaques for use in virtual imaging trials.Medical physics · 2024Article
- Cardiovascular Applications of Photon-Counting CT Technology: A Revolutionary New Diagnostic Step.Journal of cardiovascular development and disease · 2023Review
- The technical development of photon-counting detector CT.European radiology · 2023Review
- Dual-Source Photon-Counting Computed Tomography-Part I: Clinical Overview of Cardiac CT and Coronary CT Angiography Applications.Journal of clinical medicine · 2023Review
- Dual Source Photon-Counting Computed Tomography-Part II: Clinical Overview of Neurovascular Applications.Journal of clinical medicine · 2023Review
- Components of carotid atherosclerotic plaque in spectral photon-counting CT with histopathologic comparison.European radiology · 2023Observational
- In Vivo Molecular K-Edge Imaging of Atherosclerotic Plaque Using Photon-counting CT.Radiology · 2021Article
- Spectral CT imaging of human osteoarthritic cartilage via quantitative assessment of glycosaminoglycan content using multiple contrast agents.APL bioengineering · 2021Article
- Multi-energy spectral photon-counting computed tomography (MARS) for detection of arthroplasty implant failure.Scientific reports · 2021Article
- Virtual Monoenergetic CT Imaging via Deep Learning.Patterns (New York, N.Y.) · 2020Article
- Quantification of Fat Concentration and Vascular Response in Brown and White Adipose Tissue of Rats by Spectral CT Imaging.Korean journal of radiology · 2020Article
- Fabrication, Structure, and Mechanical and Ultrasonic Properties of Medical Ti6Al4V Alloys Part II: Relationship between Microstructure and Mechanical Properties and Ultrasonic Properties of Ultrasonic Scalpel.Materials (Basel, Switzerland) · 2020Article
- Dual-Energy Computed Tomography-Enabled Material Separation in Diagnosing Left Atrial Appendage Thrombus.Texas Heart Institute journal · 2019Article
- Beam profile assessment in spectral CT scanners.Journal of applied clinical medical physics · 2018Article
- Numerical observer for atherosclerotic plaque classification in spectral computed tomography.Journal of medical imaging (Bellingham, Wash.) · 2016Article
- Application of spectral computed tomography dual-substance separation technology for diagnosing left ventricular thrombus.The Journal of international medical research · 2016Article
- Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 1: Compositions and Features.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2015Review
- Photon-counting Detector CT: System Design and Clinical Applications of an Emerging Technology.Radiographics : a review publication of the Radiological Society of North America, IncReview
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo distinguish components of vulnerable atherosclerotic plaque by imaging their energy response using spectral CT and comparing images with histology.
methodsAfter spectroscopic calibration using phantoms of plaque surrogates, excised human carotid atherosclerotic plaques were imaged using MARS CT using a photon-processing detector with a silicon sensor layer and microfocus X-ray tube (50 kVp, 0.5 mA) at 38-μm voxel size. The plaques were imaged, sectioned and re-imaged using four threshold energies: 10, 16, 22 and 28 keV; then sequentially stained with modified Von Kossa, Perl's Prussian blue and Oil-Red O, and photographed. Relative Hounsfield units across the energies were entered into a linear algebraic material decomposition model to identify the unknown plaque components.
resultsLipid, calcium, iron and water-like components of plaque have distinguishable energy responses to X-ray, visible on spectral CT images. CT images of the plaque surface correlated very well with histological photographs. Calcium deposits (>1,000 μm) in plaque are larger than iron deposits (<100 μm), but could not be distinguished from each other within the same voxel using the energy range available.
conclusionsSpectral CT displays energy information in image form at high spatial resolution, enhancing the intrinsic contrast of lipid, calcium and iron within atheroma. KEY POINTS: Spectral computed tomography offers new insights into tissue characterisation. Components of vulnerable atherosclerotic plaque are spectrally distinct with intrinsic contrast. Spectral CT of excised atherosclerotic plaques can display iron, calcium and lipid. Calcium deposits are larger than iron deposits in atheroma. Spectral CT may help in the non-invasive detection of vulnerable plaques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.