ArticleHeredity2012
Genetic variation in the Yolk protein expression network of Drosophila melanogaster: sex-biased negative correlations with longevity.
Article in Heredity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Lipids in Insect Reproduction: Where, How, and Why.Advances in experimental medicine and biology · 2026Review
- Engineered spermidine-secretingFrontiers in neuroscience · 2025Article
- TheInsects · 2024Article
- Expression and Role ofInsects · 2022Article
- Molecular and behavioral studies reveal differences in olfaction between winter and summer morphs ofPeerJ · 2022Article
- Understanding the metabolome and metagenome as extended phenotypes: The next frontier in macroalgae domestication and improvement.Journal of the World Aquaculture Society · 2021Article
- Stable Isotope Labeling of Amino Acids in Flies (SILAF) Reveals Differential Phosphorylation of Mitochondrial Proteins Upon Loss of OXPHOS Subunits.Molecular & cellular proteomics : MCP · 2021Article
- Batesian mimicry has evolved with deleterious effects of the pleiotropic gene doublesex.Scientific reports · 2020Article
- The genomes of a monogenic fly: views of primitive sex chromosomes.Scientific reports · 2020Article
- Constitutive and Plastic Gene Expression Variation Associated with Desiccation Resistance Differences in theGenes · 2020Article
- The effect of Wolbachia on gene expression in Drosophila paulistorum and its implications for symbiont-induced host speciation.BMC genomics · 2019Article
- The Ecdysis Triggering Hormone System, via ETH/ETHR-B, Is Essential for Successful Reproduction of a Major Pest Insect,Frontiers in physiology · 2019Article
- Sex Differences in Drosophila Somatic Gene Expression: Variation and Regulation by doublesex.G3 (Bethesda, Md.) · 2016Article
- siRNA-Mediated Silencing of doublesex during Female Development of the Dengue Vector Mosquito Aedes aegypti.PLoS neglected tropical diseases · 2015Article
- The Wright stuff: reimagining path analysis reveals novel components of the sex determination hierarchy in Drosophila melanogaster.BMC systems biology · 2015Article
- Review
- Vitellogenin family gene expression does not increase Drosophila lifespan or fecundity.F1000Research · 2014Article
- Genotype-phenotype mapping in a post-GWAS world.Trends in genetics : TIG · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
One of the persistent problems in biology is understanding how genetic variation contributes to phenotypic variation. Associations at many levels have been reported, and yet causal inference has remained elusive. We propose to rely on the knowledge of causal relationships established by molecular biology approaches. The existing molecular knowledge forms a firm backbone upon which hypotheses connecting genetic variation, transcriptional variation and phenotypic variation can be built. The sex determination pathway is a well-established molecular network, with the Yolk protein 1-3 (Yp) genes as the most downstream target. Our analyses reveal that genetic variation in expression for genes known to be upstream in the pathway explains variation in downstream targets. Relationships differ between the two sexes, and each Yp has a distinct transcriptional pattern. Yp expression is significantly negatively correlated with longevity, an important life history trait, for both males and females.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.