ArticleJournal of clinical microbiology2012
Pleurostomophora ochracea, a novel agent of human eumycetoma with yellow grains.
Article in Journal of clinical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global burden of human mycetoma: a systematic review and meta-analysis.PLoS neglected tropical diseases · 2013Pooled it
- The contribution of mycetoma grains to suboptimal disease management.Nature communications · 2025Review
- An updated list of eumycetoma causative agents and their differences in grain formation and treatment response.Clinical microbiology reviews · 2024Review
- Mycetoma and the environment.PLoS neglected tropical diseases · 2023Review
- A New Proposed Symbiotic Plant-Herbivore Relationship betweenMicroorganisms · 2023Article
- Epidemiologic Aspects of Mycetoma in Africa.Journal of fungi (Basel, Switzerland) · 2022Review
- Mycetoma due toIDCases · 2022Article
- Hepatic phaeohyphomycosis due to a novel dematiaceous fungus,Emerging microbes & infections · 2021Article
- Mycetoma epidemiology, diagnosis management, and outcome in three hospital centres in Senegal from 2008 to 2018.PloS one · 2020Article
- Chaetomium atrobrunneum causing human eumycetoma: The first report.PLoS neglected tropical diseases · 2019Article
- Mycetoma: The Spectrum of Clinical Presentation.Tropical medicine and infectious disease · 2018Review
- Mycetoma laboratory diagnosis: Review article.PLoS neglected tropical diseases · 2017Review
- Subcutaneous Mycotic Cyst Caused by Roussoella percutanea in a UK Renal Transplant Patient.Mycopathologia · 2017Article
- Name Changes for Fungi of Medical Importance, 2012 to 2015.Journal of clinical microbiology · 2017Review
- Recommendations for competing sexual-asexually typified generic names in Sordariomycetes (except Diaporthales, Hypocreales, and Magnaporthales).IMA fungus · 2016Article
- Mycetoma in the Sudan: an update from the Mycetoma Research Centre, University of Khartoum, Sudan.PLoS neglected tropical diseases · 2015Article
- Article
- Merits and pitfalls of currently used diagnostic tools in mycetoma.PLoS neglected tropical diseases · 2014Review
- The mycetoma knowledge gap: identification of research priorities.PLoS neglected tropical diseases · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The first yellow-grain fungal mycetoma, in a 60-year-old man from Central Sudan, is reported. Morphological and phylogenetic analysis of the ribosomal small subunit (SSU), large subunit (LSU), internal transcribed spacer (ITS), β-tubulin (BT2), actin (ACT1), and elongation factor (TEF1) genes revealed that the isolate deviated from any known agent of mycetoma; it clustered in the genus Pleurostoma (anamorph genus, Pleurostomophora) in the order Calosphaeriales. The novel species, here named Pleurostomophora ochracea, is characterized by phenotypic features. The species proved to be highly susceptible to itraconazole, ketoconazole, posaconazole, and voriconazole, but not to fluconazole. The fungus was inhibited by caspofungin at 8 μg/ml, while no inhibition was found with 5-flucytosine (MIC > 64 μg/ml). Compared to other members of the genus Pleurostomophora, P. ochracea is slow growing, with a relatively high optimum growth temperature (36 to 37°C). This is the first case of a yellow-grain fungal mycetoma; yellow grains are otherwise of bacterial nature. Our case emphasizes that identification of mycetoma agents by the color of the grain only is not sufficient and may lead to inappropriate therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.