Evidence map›Paper›PMID 22759883›Full record

Trial reportBMC musculoskeletal disorders2012

Effects of home-based resistance training and neuromuscular electrical stimulation in knee osteoarthritis: a randomized controlled trial.

Robert A Bruce-Brand, Raymond J Walls, Joshua C Ong, Barry S Emerson, John M O'Byrne, Niall M Moyna

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC musculoskeletal disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02802878 (Determining the Effects of the Combined Application of Electrical Stimulation and Volitional Contractions on Muscle Strength and Knee Pain and Function in Women With or at Risk for Knee Osteoarthritis), which is not on this map. Cited by 46 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 11 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02802878 nacompletednot on this mapstarted 2016, after this paper: background citation

Determining the Effects of the Combined Application of Electrical Stimulation and Volitional Contractions on Muscle Strength and Knee Pain and Function in Women With or at Risk for Knee Osteoarthritis

TypeinterventionalSponsorUniversity of Kansas Medical CenterRan2016 to 2016Enrolled42ConditionsKnee OsteoarthritisArmsHybrid Training using Electrodes and Joint Motion Sensors, Isokinetic Training with Isokinetic Dynamometer
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 11 syntheses or guidelines pooled it, 129 citations in OpenAlex.

  1. Pooled it
  2. Exercise for osteoarthritis of the knee.The Cochrane database of systematic reviews · 2024
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  11. Exercise for osteoarthritis of the knee.The Cochrane database of systematic reviews · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Robert A Bruce-BrandCappagh National Orthopaedic Hospital, Finglas, Dublin 11, Ireland. robbrucebrand@gmail.com
Raymond J Walls
Joshua C Ong
Barry S Emerson
John M O'Byrne
Niall M Moyna
Cappagh National Orthopaedic Hospital · IEDublin City University · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundQuadriceps femoris muscle (QFM) weakness is a feature of knee osteoarthritis (OA) and exercise programs that strengthen this muscle group can improve function, disability and pain. Traditional supervised resistance exercise is however resource intensive and dependent on good adherence which can be challenging to achieve in patients with significant knee OA. Because of the limitations of traditional exercise programs, interest has been shown in the use of neuromuscular electrical stimulation (NMES) to strengthen the QFM. We conducted a single-blind, prospective randomized controlled study to compare the effects of home-based resistance training (RT) and NMES on patients with moderate to severe knee OA.

methods41 patients aged 55 to 75 years were randomised to 6 week programs of RT, NMES or a control group receiving standard care. The primary outcome was functional capacity measured using a walk test, stair climb test and chair rise test. Additional outcomes were self-reported disability, quadriceps strength and cross-sectional area. Outcomes were assessed pre- and post-intervention and at 6 weeks post-intervention (weeks 1, 8 and 14 respectively).

resultsThere were similar, significant improvements in functional capacity for the RT and NMES groups at week 8 compared to week 1 (p ≤ 0.001) and compared to the control group (p < 0.005), and the improvements were maintained at week 14 (p ≤ 0.001). Cross sectional area of the QFM increased in both training groups (NMES: +5.4%; RT: +4.3%; p = 0.404). Adherence was 91% and 83% in the NMES and RT groups respectively (p = 0.324).

conclusionsHome-based NMES is an acceptable alternative to exercise therapy in the management of knee OA, producing similar improvements in functional capacity.

trial registrationCurrent Controlled Trials ISRCTN85231954.

Indexed as

Electric Stimulation TherapyHome Care ServicesResistance TrainingAgedAnalysis of VarianceCombined Modality TherapyDisability EvaluationExercise TestFemaleHumansIrelandMagnetic Resonance ImagingMaleMiddle AgedMuscle ContractionMuscle Strength

Identifiers

PMID22759883
PMCPMC3493368
OpenAlexW1977948571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.