Evidence map›Paper›PMID 22759549›Full record

Trial reportInfection control and hospital epidemiology2012

Chlorhexidine gluconate reduces transmission of methicillin-resistant Staphylococcus aureus USA300 among Marine recruits.

Timothy J Whitman, Carey D Schlett, Greg A Grandits, Eugene V Millar, Katrin Mende, Duane R Hospenthal, Patrick R Murray, David R Tribble

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Infection control and hospital epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Staphylococcus aureus skin infection recurrences among household members: an examination of host, behavioral, and pathogen-level predictors.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Timothy J WhitmanInfectious Diseases Service, Walter Reed National Military Medical Center, Bethesda, Maryland 20889, USA. timothy.whitman@med.navy.mil
Carey D Schlett
Greg A Grandits
Eugene V Millar
Katrin Mende
Duane R Hospenthal
Patrick R Murray
David R Tribble

Funding

DATA CENTER FOR EPIDEMIOLOGIC INVESTIGATIONS OF HIVN01AI005072 · NIAID · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MCKINLAY, SONJA M · 1990 to 1994
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NIAID NIH HHS Y01 AI005072NIAID NIH HHS Y1-AI-5072
6 · The paper itself

Abstract

backgroundMethicillin-resistant Staphylococcus aureus (MRSA) pulsed-field type (PFT) USA300 causes skin and soft tissue infections in military recruits and invasive disease in hospitals. Chlorhexidine gluconate (CHG) is used to reduce MRSA colonization and infection. The impact of CHG on the molecular epidemiology of MRSA is not known.

objectiveTo evaluate the impact of 2% CHG-impregnated cloths on the molecular epidemiology of MRSA colonization.

designCluster-randomized, double-blind, controlled trial.

settingMarine Officer Candidate School, Quantico, Virginia, in 2007.

participantsMilitary recruits.

interventionThrice-weekly application of CHG-impregnated or control (Comfort Bath; Sage) cloths over the entire body. MEASUREMENTS: Baseline and serial (every 2 weeks) nasal and/or axillary swab samples were assessed for MRSA colonization. Molecular analysis was performed with pulsed-field gel electrophoresis.

resultsDuring training, 77 subjects (4.9%) acquired MRSA, 26 (3.3%) in the CHG group and 51 (6.5%) in the control group (P=.004). When analyzed for PFT, 24 subjects (3.1%) in the control group but only 6 subjects (0.8%) in the CHG group (P=.001) had USA300. Of the 167 colonizing isolates recovered from 77 subjects, 99 were recovered from the control group, including USA300 (40.4%), USA800 (38.4%), USA1000 (12.1%), and USA100 (6.1%), and 68 were recovered from the CHG group, including USA800 (51.5%), USA100 (23.5%), and USA300 (13.2%).

conclusionsCHG decreased the transmission of MRSA--more specifically, USA300--among military recruits. In addition, USA300 and USA800 outcompeted other MRSA PFTs at incident colonization. Future studies should evaluate the broad-based use of CHG to decrease transmission of USA300 in hospital settings.

Indexed as

Methicillin-Resistant Staphylococcus aureusAnti-Infective Agents, LocalAxillaCarrier StateChlorhexidineCommunity-Acquired InfectionsDNA, BacterialElectrophoresis, Gel, Pulsed-FieldHumansMilitary PersonnelMolecular EpidemiologyMolecular TypingNoseStaphylococcal InfectionsUnited StatesAnti-Infective Agents, LocalChlorhexidinechlorhexidine gluconateDNA, Bacterial

Identifiers

PMID22759549
PMCPMC5824645

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.