Evidence map›Paper›PMID 22759384›Full record

ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2013

Comparison of the long-term outcomes of kidney transplantation: USA versus Spain.

Akinlolu O Ojo, José María Morales, Miguel González-Molina, Diane E Steffick, Fu L Luan, Robert M Merion, Tammy Ojo, Francesc Moreso, Manuel Arias, Josep María Campistol and 4 more

Abstract readComparative Study
In one paragraph

Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Novel intervention based on an individualized bundle of care to decrease infection in kidney transplant recipients.Transplant infectious disease : an official journal of the Transplantation Society · 2024
    Article
  3. Better kidney allograft survival despite higher-risk donor and recipient characteristics between 1995 and 2014.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Article
  4. A comparison of the epidemiology of kidney replacement therapy between Europe and the United States: 2021 data of the ERA Registry and the USRDS.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Article
  5. Article
  6. Article
  7. A comparison of outcomes after lung transplantation between European and North American centers.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022
    Article
  8. Observational
  9. Organization of Post-Transplant Care and the 5-Year Outcomes of Kidney Transplantation.International journal of environmental research and public health · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Akinlolu O OjoDepartment of Medicine, University of Michigan, Ann Arbor, MI, USA. aojo@umich.edu
José María Morales
Miguel González-Molina
Diane E Steffick
Fu L Luan
Robert M Merion
Tammy Ojo
Francesc Moreso
Manuel Arias
Josep María Campistol
Domingo Hernandez
Daniel Serón
Scientific Registry of Transplant Recipients and
Spanish Chronic Allograft Study Group

Funding

Renal and Cardiovascular Events in Patients with Chronic Kidney DiseaseK24DK062234 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OJO, AKINLOLU OLUSEUN · 2002 to 2013
$1.6M
NIDDK NIH HHS K24 DK062234
6 · The paper itself

Abstract

backgroundThe long-term outcomes of kidney transplantation are suboptimal because many patients lose their allografts or experience premature death. Cross-country comparisons of long-term outcomes of kidney transplantation may provide insight into factors contributing to premature graft failure and death. We evaluated the rates of late graft failure and death among US and Spanish kidney recipients.

methodsThis is a cohort study of US (n = 9609) and Spanish (n = 3808) patients who received a deceased donor kidney transplant in 1990, 1994, 1998 or 2002 and had a functioning allograft 1 year after transplantation with follow-up through September 2006. Ten-year overall and death-censored graft survival and 10-year overall recipient survival and death with graft function (DWGF) were estimated with multivariate Cox models.

resultsAmong recipients alive with graft function 1 year after transplant, the 10-year graft survival was 71.3% for Spanish and 53.4% for US recipients (P < 0.001). The 10-year, death-censored graft survival was 75.6 and 76.0% for Spanish and US recipients, respectively (P = 0.73). The 10-year recipient survival was 86.2% for Spanish and 67.4% for US recipients (P < 0.001). In recipients with diabetes as the cause of ESRD, the adjusted DWGF rates at 10 years were 23.9 and 53.8 per 1000 person-years for Spanish and US recipients, respectively (P < 0.001). Among recipients whose cause of ESRD was not diabetes mellitus, the adjusted 10-year DWGF rates were 11.0 and 25.4 per 1000 person-years for Spanish and US recipients, respectively.

conclusionsUS kidney transplant recipients had more than twice the long-term hazard of DWGF compared with Spanish kidney transplant recipients and similar levels of death-censored graft function. Pre-transplant medical care, comorbidities, such as cardiovascular disease, and their management in each country's health system are possible explanations for the differences between the two countries.

Indexed as

Graft SurvivalKidney TransplantationAdolescentAdultAgedAged, 80 and overChildChild, PreschoolCohort StudiesDiabetes ComplicationsFemaleHumansInfantKidney Failure, ChronicMaleMiddle Aged

Identifiers

PMID22759384
PMCPMC3616762

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.