ArticleEndocrinology2012
Uterine deletion of Trp53 compromises antioxidant responses in the mouse decidua.
Article in Endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Regulatory Interplay of p53, AMPK, and mTOR in Decidualization: Implications for Reproductive Competence and Cancer Biology.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- A novel support vector machine-based 1-day, single-dose prediction model of genotoxic hepatocarcinogenicity in rats.Archives of toxicology · 2024Article
- Role of Inflammaging on the Reproductive Function and Pregnancy.Clinical reviews in allergy & immunology · 2023Review
- Article
- The single-cell atlas of cultured human endometrial stromal cells.F&S science · 2022Article
- Endometrial Decidualization: The Primary Driver of Pregnancy Health.International journal of molecular sciences · 2020Review
- Maternal dietary selenium intake is associated with increased gestational length and decreased risk of preterm delivery.The British journal of nutrition · 2020Article
- Circulating Exosomal miRNA Profile During Term and Preterm Birth Pregnancies: A Longitudinal Study.Endocrinology · 2019Article
- New Insights into the Process of Placentation and the Role of Oxidative Uterine Microenvironment.Oxidative medicine and cellular longevity · 2019Review
- Oxidative stress-induced TGF-beta/TAB1-mediated p38MAPK activation in human amnion epithelial cells.Biology of reproduction · 2018Article
- Review
- Preterm labor in the absence of acute histologic chorioamnionitis is characterized by cellular senescence of the chorioamniotic membranes.American journal of obstetrics and gynecology · 2017Article
- Genetic Associations with Gestational Duration and Spontaneous Preterm Birth.The New England journal of medicine · 2017Article
- A role for cellular senescence in birth timing.Cell cycle (Georgetown, Tex.) · 2017Review
- Programmed Fetal Membrane Senescence and Exosome-Mediated Signaling: A Mechanism Associated With Timing of Human Parturition.Frontiers in endocrinology · 2017Review
- Simultaneous Proteomic Discovery and Targeted Monitoring using Liquid Chromatography, Ion Mobility Spectrometry, and Mass Spectrometry.Molecular & cellular proteomics : MCP · 2016Article
- The fungal cultivar of leaf-cutter ants produces specific enzymes in response to different plant substrates.Molecular ecology · 2016Article
- Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site.Scientific reports · 2016Article
- Evidence of perturbations of the cytokine network in preterm labor.American journal of obstetrics and gynecology · 2015Article
- Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus.The Journal of biological chemistry · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Preterm birth is a global health issue impacting millions of mothers and babies. However, the etiology of preterm birth is not clearly understood. Our recent finding that premature decidual senescence with terminal differentiation is a cause of preterm birth in mice with uterine Trp53 deletion, encoding p53 protein, led us to explore other potential factors that are related to preterm birth. Using proteomics approaches, here, we show that 183 candidate proteins show significant changes in deciduae with Trp53 deletion as compared with normal deciduae. Functional categorization of these proteins unveiled new pathways that are influenced by p53. In particular, down-regulation of a cluster of antioxidant enzymes in p53-deficient deciduae suggests that increased oxidative stress could be one cause of preterm birth in mice harboring uterine deletion of Trp53.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.