ArticleEvolution; international journal of organic evolution2012
General principles of single-construct chromosomal gene drive.
Article in Evolution; international journal of organic evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Parental-effect gene-drive elements under partial selfing, or why do Caenorhabditis genomes have hyperdivergent regions?Genetics · 2025Article
- Parental-effect gene-drive elements under partial selfing, or why dobioRxiv : the preprint server for biology · 2024Article
- Cleave and Rescue gamete killers create conditions for gene drive in plants.Nature plants · 2024Article
- Cleave and Rescue gamete killers create conditions for gene drive in plants.bioRxiv : the preprint server for biology · 2024Article
- Harnessing Wolbachia cytoplasmic incompatibility alleles for confined gene drive: A modeling study.PLoS genetics · 2023Article
- Design and analysis of CRISPR-based underdominance toxin-antidote gene drives.Evolutionary applications · 2021Article
- Split versions of Cleave and Rescue selfish genetic elements for measured self limiting gene drive.PLoS genetics · 2021Article
- Gene Drive Dynamics in Natural Populations: The Importance of Density Dependence, Space, and Sex.Annual review of ecology, evolution, and systematics · 2020Article
- Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post-market environmental monitoring of genetically modified insects containing engineered gene drives.EFSA journal. European Food Safety Authority · 2020Article
- Gene drive and resilience through renewal with next generationProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Population Dynamics of Underdominance Gene Drive Systems in Continuous Space.ACS synthetic biology · 2020Article
- Performance analysis of novel toxin-antidote CRISPR gene drive systems.BMC biology · 2020Article
- A toxin-antidote CRISPR gene drive system for regional population modification.Nature communications · 2020Article
- Tethered homing gene drives: A new design for spatially restricted population replacement and suppression.Evolutionary applications · 2019Article
- Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Molecular tools to create new strains for mosquito sexing and vector control.Parasites & vectors · 2018Review
- Considerations for the governance of gene drive organisms.Pathogens and global health · 2018Review
- Gene drives to fight malaria: current state and future directions.Pathogens and global health · 2017Review
- Cheating evolution: engineering gene drives to manipulate the fate of wild populations.Nature reviews. Genetics · 2016Review
- Evolutionary decay and the prospects for long-term disease intervention using engineered insect vectors.Evolution, medicine, and public health · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Gene drive systems are genetic elements capable of spreading into a population even if they confer a fitness cost to their host. We consider a class of drive systems consisting of a chromosomally located, linked cluster of genes, the presence of which renders specific classes of offspring arising from specific parental crosses unviable. Under permissive conditions, a number of these elements are capable of distorting the offspring ratio in their favor. We use a population genetic framework to derive conditions under which these elements spread to fixation in a population or induce a population crash. Many of these systems can be engineered using combinations of toxin and antidote genes, analogous to Medea, which consists of a maternal toxin and zygotic antidote. The majority of toxin-antidote drive systems require a critical frequency to be exceeded before they spread into a population. Of particular interest, a Z-linked Medea construct with a recessive antidote is expected to induce an all-male population crash for release frequencies above 50%. We suggest molecular tools that may be used to build these systems, and discuss their relevance to the control of a variety of insect pest species, including mosquito vectors of diseases such as malaria and dengue fever.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.