ArticleIranian Red Crescent medical journal2012
Anti-inflammatory effect of oleuropein in experimental rat spinal cord trauma.
Article in Iranian Red Crescent medical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Olive Leaves as a Potential Phytotherapy in the Treatment of COVID-19 Disease; A Mini-Review.Frontiers in pharmacology · 2022Pooled it
- Trial
- Oleuropein Reduces Secondary Injury Pathways After Experimental Spinal Cord Injury Via HMGB1-Associated Signaling.Medeniyet medical journal · 2026Article
- Oleuropein modulates over-proliferation of keratinocytes in mice with imiquimod-mediated psoriasis and inhibits differentiation of Th17 cells through the JAK3/STAT3 axis.Archives of medical science : AMS · 2026Article
- Oleuropein modulates anti-inflammatory activity of celecoxib and ketoprofen through cyclooxygenase pathway: in vivo, in silico and pharmacokinetics approaches.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Oleuropein attenuates cardiac and lung injury induced by 5-fluorouracil via modulating oxidative stress and TNF-α/IL-6 signaling pathway.Journal of molecular histology · 2025Article
- Protective effect of oleuropein on the brain tissue in D-Galactose-induced aging in rat model.Molecular biology reports · 2024Article
- Effect of the olive leaf extract in chronic spinal cord injury model: an experimental research.Annals of medicine and surgery (2012) · 2023Article
- Updated Organic Composition and Potential Therapeutic Properties of Different Varieties of Olive Leaves fromPlants (Basel, Switzerland) · 2023Article
- Edible Films Made of Dried Olive Leaf Extract and Chitosan: Characterization and Applications.Foods (Basel, Switzerland) · 2022Article
- Does Anzer Propolis Have a Protective Effect on Rabbit Spinal Cord Ischemia/Reperfusion Injury?Brazilian journal of cardiovascular surgery · 2022Article
- Oleuropein alleviates gestational diabetes mellitus by activating AMPK signaling.Endocrine connections · 2021Article
- Leptin and Nutrition in Gestational Diabetes.Nutrients · 2020Review
- LncGBP9/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1/STAT6 and SOCS3.Journal of neuroinflammation · 2020Article
- The effect of oleuropein on unilateral ureteral obstruction induced-kidney injury in rats: the role of oxidative stress, inflammation and apoptosis.Molecular biology reports · 2020Article
- Therapeutic Effects of Oleuropein in Improving Seizure, Oxidative Stress and Cognitive Disorder in Pentylenetetrazole Kindling Model of Epilepsy in Mice.Iranian journal of pharmaceutical research : IJPR · 2020Article
- Oleuropein, a Bioactive Compound fromAntioxidants (Basel, Switzerland) · 2019Review
- Methotrexate combined with methylprednisolone for the recovery of motor function and differential gene expression in rats with spinal cord injury.Neural regeneration research · 2017Article
- MicroRNA-211/BDNF axis regulates LPS-induced proliferation of normal human astrocyte through PI3K/AKT pathway.Bioscience reports · 2017Article
- Protective effects of oleuropein against renal injury oxidative damage in alloxan-induced diabetic rats; a histological and biochemical study.Journal of nephropathology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpinal cord injury stimulates an inflammatory reaction that causes substantial secondary damage inside the injured spinal tissue. The purpose of this study was to determine the anti-inflammatory effect of oleuropein on traumatized spinal cord.
methodsRats were randomly divided into four groups of 7 rats each as follows: Sham-operated group, trauma group, and oleuropein treatment groups (20 mg/kg, ip, immediately and 1 hour after spinal cord injury). Spinal cord samples were taken 24 hours after injury and studied for immunohistochemistry of tumor necrosis factor-α (TNF-α), interleukin-1ß (IL-1ß), nitrotyrosine, inducible nitricoxide synthase (iNOS), cyclooxygenase-2 (COX-2), and poly(ADP-ribose) polymerase (PARP).
resultsAttenuated TNF-α, IL-1ß, nitrotyrosine, iNOS, COX-2, and PARP expression could be detected in the oleuropein-treated rats.
conclusionOleuropein modulates inflammatory reactions following spinal cord injury.
Indexed as
Identifiers
22754686PMC3385802W2136303676What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.