ArticleOpen biology2012
Initiating head development in mouse embryos: integrating signalling and transcriptional activity.
Article in Open biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- A novel, PCP-dependent tissue organising principle coordinating morphogenesis between embryonic skin epidermal layers.Journal of anatomy · 2026Article
- Investigation of embryogenesis in a dish: the development and application of gastruloid models from pluripotent stem cells.Cell & bioscience · 2026Review
- Development of node architecture and emergence of molecular organizer characteristics in the pig embryo.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Three-dimensional stem cell models of mammalian gastrulation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Review
- Wnt and BMP signalling direct anterior-posterior differentiation in aggregates of mouse embryonic stem cells.Biology open · 2023Article
- PRDM15 interacts with DNA-PK-Ku complex to promote radioresistance in rectal cancer by facilitating DNA damage repair.Cell death & disease · 2022Article
- A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation.Biology open · 2022Article
- An efficient simplified method for the generation of corneal epithelial cells from human pluripotent stem cells.Human cell · 2022Article
- The dynamics of morphogenesis in stem cell-based embryology: Novel insights for symmetry breaking.Developmental biology · 2021Review
- Article
- Disruption of entireeLife · 2021Article
- Loss ofFrontiers in cell and developmental biology · 2021Article
- Differentiation Induction of Human Stem Cells for Corneal Epithelial Regeneration.International journal of molecular sciences · 2020Review
- PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly.Science advances · 2020Article
- An epiblast stem cell-derived multipotent progenitor population for axial extension.Development (Cambridge, England) · 2019Article
- Filling the Gap: Neural Stem Cells as A Promising Therapy for Spinal Cord Injury.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Identification of reference genes suitable for RT-qPCR studies of murine gastrulation and patterning.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Universal Corneal Epithelial-Like Cells Derived from Human Embryonic Stem Cells for Cellularization of a Corneal Scaffold.Translational vision science & technology · 2018Article
- Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism.Nature communications · 2017Article
- Functional characterisation ofDevelopment (Cambridge, England) · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The generation of an embryonic body plan is the outcome of inductive interactions between the progenitor tissues that underpin their specification, regionalization and morphogenesis. The intercellular signalling activity driving these processes is deployed in a time- and site-specific manner, and the signal strength must be precisely controlled. Receptor and ligand functions are modulated by secreted antagonists to impose a dynamic pattern of globally controlled and locally graded signals onto the tissues of early post-implantation mouse embryo. In response to the WNT, Nodal and Bone Morphogenetic Protein (BMP) signalling cascades, the embryo acquires its body plan, which manifests as differences in the developmental fate of cells located at different positions in the anterior-posterior body axis. The initial formation of the anterior (head) structures in the mouse embryo is critically dependent on the morphogenetic activity emanating from two signalling centres that are juxtaposed with the progenitor tissues of the head. A common property of these centres is that they are the source of antagonistic factors and the hub of transcriptional activities that negatively modulate the function of WNT, Nodal and BMP signalling cascades. These events generate the scaffold of the embryonic head by the early-somite stage of development. Beyond this, additional tissue interactions continue to support the growth, regionalization, differentiation and morphogenesis required for the elaboration of the structure recognizable as the embryonic head.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.