ArticleFrontiers in physiology2012
Discharge Identity of Medullary Inspiratory Neurons is Altered during Repetitive Fictive Cough.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- An inspiration-off attractor supports the robust and flexible control of breathing.Science advances · 2026Article
- An inspiration-off attractor supports the robust and flexible control of breathing.bioRxiv : the preprint server for biology · 2025Article
- Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network.eLife · 2021Article
- Neuronal mechanisms underlying opioid-induced respiratory depression: our current understanding.Journal of neurophysiology · 2021Review
- Blood pressure drives multispectral tuning of inspiration via a linked-loop neural network.Journal of neurophysiology · 2020Article
- Inputs to medullary respiratory neurons from a pontine subregion that controls breathing frequency.Respiratory physiology & neurobiology · 2019Article
- A spatially dynamic network underlies the generation of inspiratory behaviors.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Defining the Rhythmogenic Elements of Mammalian Breathing.Physiology (Bethesda, Md.) · 2018Review
- The Dynamic Basis of Respiratory Rhythm Generation: One Breath at a Time.Annual review of neuroscience · 2018Review
- Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia.Physiology (Bethesda, Md.) · 2018Review
- Characteristics of breathing rate control mediated by a subregion within the pontine parabrachial complex.Journal of neurophysiology · 2017Article
- Role of the dorsal medulla in the neurogenesis of airway protection.Pulmonary pharmacology & therapeutics · 2015Review
- Peripheral chemoreceptors tune inspiratory drive via tonic expiratory neuron hubs in the medullary ventral respiratory column network.Journal of neurophysiology · 2015Article
- Systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders.Frontiers in physiology · 2014Article
- Resuscitation and auto resuscitation by airway reflexes in animals.Cough (London, England) · 2013Article
- A joint computational respiratory neural network-biomechanical model for breathing and airway defensive behaviors.Frontiers in physiology · 2012Article
- Neurogenesis of cough, other airway defensive behaviors and breathing: A holarchical system?Respiratory physiology & neurobiology · 2006Review
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Authors and funding
10 authors.
Funding
Abstract
This study investigated the stability of the discharge identity of inspiratory decrementing (I-Dec) and augmenting (I-Aug) neurons in the caudal (cVRC) and rostral (rVRC) ventral respiratory column during repetitive fictive cough in the cat. Inspiratory neurons in the cVRC (n = 23) and rVRC (n = 17) were recorded with microelectrodes. Fictive cough was elicited by mechanical stimulation of the intrathoracic trachea. Approximately 43% (10 of 23) of I-Dec neurons shifted to an augmenting discharge pattern during the first cough cycle (C1). By the second cough cycle (C2), half of these returned to a decrementing pattern. Approximately 94% (16 of 17) of I-Aug neurons retained an augmenting pattern during C1 of a multi-cough response episode. Phrenic burst amplitude and inspiratory duration increased during C1, but decreased with each subsequent cough in a series of repetitive coughs. As a step in evaluating the model-driven hypothesis that VRC I-Dec neurons contribute to the augmentation of inspiratory drive during cough via inhibition of VRC tonic expiratory neurons that inhibit premotor inspiratory neurons, cross-correlation analysis was used to assess relationships of tonic expiratory cells with simultaneously recorded inspiratory neurons. Our results suggest that reconfiguration of inspiratory-related sub-networks of the respiratory pattern generator occurs on a cycle-by-cycle basis during repetitive coughing.
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