ArticleInternational journal of molecular sciences2012
CD133-positive cells might be responsible for efficient proliferation of human meningioma cells.
Article in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Array expression meta-analysis of cancer stem cell genes identifies upregulation of PODXL especially in DCC low expression meningiomas.PloS one · 2019Pooled it
- Meningioma enlargement associated with luteinizing hormone-releasing hormone agonist therapy: two cases and supporting in vitro evidence.Brain tumor pathology · 2026Article
- Cyclic cytokines mediated the effect of immune cells on meningioma: a two-step, mediation mendelian randomization study.BMC cancer · 2025Article
- Cancer stem cells in meningiomas: novel insights and therapeutic implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Review
- Cas9 Mouse Model of Skull Base Meningioma Driven by Combinational Gene Inactivation in Meningeal Cells.CNS neuroscience & therapeutics · 2025Article
- Malignant Transformation of Meningiomas.Journal of Cancer · 2025Review
- Article
- Decoding meningioma heterogeneity and neoplastic cell-macrophage interaction through single-cell transcriptome profiling across pathological grades.Journal of translational medicine · 2023Article
- Characterization and comparison of genomic profiles between primary cancer cell lines and parent atypical meningioma tumors.Cancer cell international · 2020Article
- Meningioma Tumor Microenvironment.Advances in experimental medicine and biology · 2020Review
- SSTR-2 as a potential tumour-specific marker for fluorescence-guided meningioma surgery.Acta neurochirurgica · 2018Article
- Effect of postoperative systemic antipsychotic therapy on psychiatric recurrence in patients with meningiomas.Oncology letters · 2018Article
- In situ characterization of stem cells-like biomarkers in meningiomas.Cancer cell international · 2018Article
- Pleomorphism and drug resistant cancer stem cells are characteristic of aggressive primary meningioma cell lines.Cancer cell international · 2017Article
- Survival, proliferation, and migration of human meningioma stem-like cells in a nanopeptide scaffold.Iranian journal of basic medical sciences · 2016Article
- Article
- Multiple meningiomas characterized by benign and malignant tumor entities.CNS neuroscience & therapeutics · 2013Article
- VEGF promotes proliferation of human glioblastoma multiforme stem-like cells through VEGF receptor 2.TheScientificWorldJournal · 2013Article
- Immunohistochemistry expression of stem cell markers SOX2, OCT4, CD133 in different grades of meningiomas and correlation with Ki 67 index.Medical journal, Armed Forces IndiaArticle
- THE EXPRESSION OF STEM CELL MARKERS (CD133, NESTIN, OCT4, SOX2) IN INVASIVE PITUITARY ADENOMAS.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Owing to lack of appropriate model systems, investigations of meningioma biology have come to a stop. In this study, we developed a comprehensive digestion method and defined a culture system. Using this method and system, primary meningioma cells in conditioned suspension medium and a hypoxic environment could be amplified in spheres and were passaged for more than ten generations. Meningioma sphere cells were positive for meningioma cell markers and negative for markers of neural cell types. Importantly, we found the cells expressed the stem cell marker, CD133, but not nestin. All of the tumor sphere cell populations showed a slower degree of cell proliferation than that of human glioma cells and fetal neural stem cells (NSCs). Further studies showed that the proliferative rate was positively correlated with CD133 expression. The higher the CD133 expression, the faster the cell proliferation. With the increase in cell generations, the cell proliferation rate gradually slowed down, and CD133 expression also decreased. Single CD133(+) cells rather than CD133(-) cells could form spheres. Thus, the results above indicated that those cells expressing CD133 in spheres might be stem-like cells, which may be responsible for efficient amplification of human meningioma cells. Decreased expression of CD133 may lead to the failure of long-term passaging.
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