ReviewDialogues in clinical neuroscience2012
Pharmacological approaches to the treatment of complicated grief: rationale and a brief review of the literature.
Review in Dialogues in clinical neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The neurobiological reward system in Prolonged Grief Disorder (PGD): A systematic review.Psychiatry research. Neuroimaging · 2020Pooled it
- Poor Decision Making and Sociability Impairment Following Central Serotonin Reduction in Inducible TPH2-Knockdown Rats.International journal of molecular sciences · 2024Article
- Prolonged grief disorder in ICD-11 andThe Australian and New Zealand journal of psychiatry · 2023Review
- What we know about grief intervention: a bibliometric analysis.Frontiers in psychiatry · 2023Review
- Prolonged Grief Disorder: Course, Diagnosis, Assessment, and Treatment.Focus (American Psychiatric Publishing) · 2021Review
- Article
- Review of Grief Therapies for Older Adults.Current geriatrics reports · 2021Review
- Hospice Bereavement Service Delivery to Family Members and Friends With Bereavement-Related Mental Health Symptoms.The American journal of hospice & palliative care · 2019Article
- [Prolonged grief disorder].Der Nervenarzt · 2018Article
- Utilization of Hospice Bereavement Support by At-Risk Family Members.The American journal of hospice & palliative care · 2016Article
- Prolonged grief: setting the research agenda.European journal of psychotraumatology · 2015Article
- Treating complicated grief.JAMA · 2013Article
- Initiation of psychotropic medication after partner bereavement: a matched cohort study.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complicated grief (CG) is a common and often under-acknowledged cause of profound impairment experienced after the loss of a loved one. Although both clinical and basic research suggests that pharmacological agents might be of use in the treatment of CG, research on pharmacological approaches to this condition is still scarce. Three open-label trials and one randomized trial on bereavement-related depression suggest that tricyclic antidepressants may be effective, although they may be more efficacious for depressive symptoms than for grief-specific symptoms. Four open-label trials (total number of participants, 50) of selective serotonin reuptake inhibitors (SSRIs) have yielded results, providing very preliminary support that they might be effective in the treatment of CG, both as a standalone treatment and in conjunction with psychotherapeutic interventions. These more recent studies have shown an effect on both depression and grief-specific scales. Furthermore, therapeutic interventions for CG may be more effective in conjunction with SSRI administration. Given the small number of pharmacological studies to date, there is a need for randomized trials to test the potential efficacy of pharmacological agents in the treatment of CG.
Indexed as
Identifiers
22754287PMC3384443What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.