ArticleJournal of young pharmacists : JYP2012
Diuretic effects of cleistanthin a and cleistanthin B from the leaves of cleistanthus collinus in wistar rats.
Article in Journal of young pharmacists : JYP, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Cleistanthin A derivative disrupts autophagy and suppresses head and neck squamous cell carcinoma progression via targeted vacuolar ATPase.Scientific reports · 2024Article
- Effects ofJBRA assisted reproduction · 2022Article
- Elusive Toxin inACS omega · 2021Article
- Anti-Inflammatory and Antinociceptive Studies of Hydroalcoholic Extract from the Leaves ofMolecules (Basel, Switzerland) · 2018Article
- Evaluation ofJournal of traditional and complementary medicine · 2016Article
- Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B.Journal of basic and clinical pharmacy · 2014Article
- Identification of natural inhibitors against angiotensin I converting enzyme for cardiac safety using induced fit docking and MM-GBSA studies.Pharmacognosy magazine · 2014Article
- Sub-chronic toxicological evaluation of cleistanthin A and cleistanthin B from the leaves ofToxicology reports · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study the diuretic effects of cleistanthin A and cleistanthin B, phytoconstituents were isolated from the leaves of Cleistanthus collinus in Wistar rats. The in vivo diuretic effects of cleistanthins A and B were determined according to the Lipschitz test. Prior to the experiment, the animals were fasted for 5 h and placed individually in metabolic cages. Cleistanthins A and B (12.5, 25, and 50 mg/kg) and furosemide (5 mg/kg) were suspended in 0.5% w/v carboxymethyl cellulose and administered orally. The urine was collected up to 5 h after administration and subsequently up to 24 h after administration. The acidity and urine volume were measured immediately. The urinary sodium and potassium levels were determined using a flame photometer, and the chloride level was determined by argentometric titration. The diuretic index and diuretic activity were calculated mathematically. While cleistanthins A and B showed a diuretic index of more than one, the diuretic activity of these compounds was less than one, indicating inferior activity compared with furosemide. Both cleistanthin A and B produced a significant increase in the urine volume and alterations in urinary electrolyte levels. However, the effect of the compounds was not dose dependent. Cleistanthin A and cleistanthin B exert diuretic effects in male Wistar rats without affecting the urinary acidity.
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Registered trials
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