ArticleIndian journal of human genetics2012
Recombination in human leukocyte antigen region in two Asian Indian families.
Article in Indian journal of human genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed, 4 citations in OpenAlex.
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2 authors at 1 institution in 1 country.
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Abstract
backgroundRecombination (crossing over) may generate novel haplotypes that can be beneficial to a population against recently introduced pathogens. It may lead to the generation of new alleles. SETTINGS AND
designA prospective study at a tertiary care centre.
aimTo report two rare cases of crossing over in HLA region. MATERIALS AND
methodsTissue-typing was done by sequence specific primers (SSP) for DR locus and by both SSP and serology for Class I which was reconfirmed on fresh samples.
resultsIn one patient crossing over had taken place in the region of A locus resulting in inheritance of A*01 instead of expected A*11. In second family crossing over had taken place in region of DRB1 locus and the sibling inherited DRB1*08 instead of DRB1*10.
conclusionsPossibility of recombination must be considered when interpreting implausible tissue-typing results of families worked up for BMT.
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