ArticleIndian journal of human genetics2012
Karyotypic findings in chronic myeloid leukemia cases undergoing treatment.
Article in Indian journal of human genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChronic myeloid leukemia (CML) is a clonal myeloproliferative expansion of primitive hematopoietic progenitor cells. MATERIALS AND
methodsIn the present study, CML samples were collected from various hospitals in Amritsar, Jalandhar and Ludhiana.
resultsChromosomal alterations seen in peripheral blood lymphocytes of these treated and untreated cases of CML were satellite associations, double minutes, random loss, gain of C group chromosomes and presence of marker chromosome. No aberrations were observed in control samples. Karyotypic abnormalities have also been noted in the Ph-negative cells of some patients in disease remission.
conclusionThis is a novel phenomenon whose prognostic implications require thorough and systematic evaluation.
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