ArticleIndian journal of clinical biochemistry : IJCB2011
Extra pulmonary tuberculosis: a diagnostic dilemma.
Article in Indian journal of clinical biochemistry : IJCB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Association between livestock exposures and human tuberculosis in Wardha, Central India: An exploratory case-control study.PloS one · 2026Article
- Head and Neck Tuberculosis: A Rare Diagnosis and the Role of Surgical Biopsy and Histopathological Evaluation in Extrapulmonary Disease.Pathogens (Basel, Switzerland) · 2025Article
- Surgical Manifestations of Hepatobiliarypancreatic Tuberculosis (HBPTB).Acta medica Philippina · 2025Article
- Diagnostic value of third-generation nanopore sequencing in extrapulmonary tuberculosis.Frontiers in cellular and infection microbiology · 2024Article
- Diagnosis of extrapulmonary tuberculosis by ultrasound-guided biopsy: A retrospective comparison study.Frontiers in cellular and infection microbiology · 2023Article
- Review
- Unusual manifestations of extra-pulmonary tuberculosis: a pictorial essay.Polish journal of radiology · 2022Article
- Cancer obscures extrapulmonary tuberculosis (EPTB) at a tertiary hospital in Northern Malawi.Epidemiology and infection · 2020Article
- Six months therapy for tuberculous meningitis.The Cochrane database of systematic reviews · 2016Review
- Tissue Xpert™ MTB/Rif assay is of limited use in diagnosing peritoneal tuberculosis in patients with exudative ascites.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2015Article
- False-positive tuberculous meningitis due to laboratory contamination: importance of a holistic clinical evaluation.BMJ case reports · 2014Article
- Pathogen-derived biomarkers for active tuberculosis diagnosis.Frontiers in microbiology · 2014Review
- Antimicrobial and Antioxidant Activities of Bauhinia racemosa Lam. and Chemical Content.Iranian journal of pharmaceutical research : IJPR · 2014Article
- Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System.Basic and clinical neuroscienceArticle
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Abstract
Tuberculosis remains a major public health problem globally, with India being one of the high burden countries. The common causative agent is Mycobacterium tuberculosis but in developing countries M. bovis is reported as a potential human pathogen. Almost 20% of all reported cases of tuberculosis are of extra pulmonary form of disease. Diagnosis of extra pulmonary tuberculosis (EPTB) is not always possible with conventional methods, due to the long time required and the paucibacillary nature of samples; hence the need of rapid molecular methods. A prospective study was conducted on 300 patients of EPTB over a period of 5 years. These patients were suspected cases of tubercular meningitis, tubercular ascites and tubercular lymphadenitis. Samples analyzed were cerebrospinal fluid, ascitic fluid and lymph node fine needle aspirate. A two step PCR targeting hup B gene was used. Clinical response to anti tubercular therapy (ATT) was taken as positive (gold standard). PCR for hup B gene was positive in 147 samples out of 155 ATT responders. Of these 85.71% were infected with M. tuberculosis, 9.52% with M. bovis alone and 4.76% showed co infection with both M.tb and M. bovis. The sensitivity and specificity of PCR was 90.32 and 94.48% respectively.
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