Trial reportAfrican journal of traditional, complementary, and alternative medicines : AJTCAM2011
Fluoroquinolone-resistant uncomplicated urinary tract infections, Chinese herbal medicine may provide help.
Trial report in African journal of traditional, complementary, and alternative medicines : AJTCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Chinese herbal medicine: a safe alternative therapy for urinary tract infection in patients with renal insufficiency.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2012Trial
- Low Concentration of Wenyang Tonglin Decoction Promotes Conjugation and Transfer of Drug-Resistant Plasmids among Heterologous Strains.Chinese journal of integrative medicine · 2024Article
- Functional immune boosters; the herb or its dead microbiome? Antigenic TLR4 agonist MAMPs found in 65 medicinal roots and algae's.Journal of functional foods · 2023Article
- Prophylactic herbal therapy prevents experimental ascending urinary tract infection in mice.Chinese journal of integrative medicine · 2016Article
- Transfer of Herb-Resistance Plasmid From Escherichia coli to Staphylococcus aureus Residing in the Human Urinary Tract.Jundishapur journal of microbiology · 2014Article
- Virulence genotype and phylogenetic groups in relation to Chinese herb resistance among Escherichia coli from patients with acute pyelonephritis.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2014Article
- Chinese herb-resistance and adherence to human uroepithelial cells of uropathogenic Escherichia coli.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We assessed the effects of Chinese herbs on the uncomplicated urinary tract infections (UTIs) in women caused by fluoroquinolone-resistant strains. A total of 56 pre-menopausal women with uncomplicated UTIs caused by fluoroquinolone-resistant strains were included. Urine cultures were carried out. All organisms were proved to be fluoroquinolone-resistant at baseline. The patients were orally administrated Chinese herbal concoction for ten days. Chinese herbal concoction eradicated the primary pathogen in 71.4% of the patients at the 1-week follow-up. Among the 20 patients who had bacteriologic failures in the Day 5 of treatment, 2 developed superinfection. Of the failures in the group, Proteus mirabilis, Staphylococcus epidermidis and Providencia rettgeri were implicated in 50.0%, 50.0% and 100.0% of the failures, respectively. The clinical outcomes were also good, with cure or improvement for more than 80% of all subjects. About 14% of the study subjects reported at least one potential adverse event. The adverse events most frequently reported were nausea and diarrhea. All patients tolerated the symptoms. The adverse reactions did not prevail after discontinuation of the medication. Chinese herbal therapy may be an acceptable alternative for the treatment of uncomplicated UTIs caused by fluoroquinolone-resistant uropathogens.
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