ArticleSleep2012
A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor.
Article in Sleep, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Risk or benefit? Side effects of caffeine supplementation in sport: a systematic review.European journal of nutrition · 2022Pooled it
- Coffee consumption is associated with DNA methylation levels of human blood.European journal of human genetics : EJHG · 2017Pooled it
- Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.Molecular psychiatry · 2015Pooled it
- Melatonin, Caffeine, or Their Combination: Effects on Sleep, Performance, Perceived Exertion in a Placebo-Controlled Crossover Study.Nutrients · 2026Trial
- Genetic Polymorphisms in ADORA2A and CYP1A2 Influence Caffeine's Effect on Postprandial Glycaemia.Scientific reports · 2019Trial
- Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine AProceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Effects of caffeine on the human circadian clock in vivo and in vitro.Science translational medicine · 2015Trial
- Coffee, the Gut Microbiome, and Host Metabolism: Gastrointestinal Fate, Microbial Transformation, Mechanistic Insights, and Prospects for Precision Nutrition.Metabolites · 2026Review
- Genetic architecture of a Circadian Imbalance Index: genome-wide association, phenome-wide association, and Mendelian randomisation analyses.EBioMedicine · 2026Article
- Genome wide association study of a Circadian Imbalance Index in 312,935 European ancestry UK Biobank participants identifies loci related to diabetes, mood and myocardial infarction.Research square · 2025Article
- Caffeine and Sports Performance: The Conflict between Caffeine Intake to Enhance Performance and Avoiding Caffeine to Ensure Sleep Quality.Sports medicine (Auckland, N.Z.) · 2025Review
- A comprehensive review of natural compounds and their structure-activity relationship in Parkinson's disease: exploring potential mechanisms.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Sleep Quality and Duration in Children That Consume Caffeine: Impact of Dose and Genetic Variation inGenes · 2023Article
- Genetic determinants of liking and intake of coffee and other bitter foods and beverages.Scientific reports · 2021Article
- Adenosine Receptor Antagonists to Combat Cancer and to Boost Anti-Cancer Chemotherapy and Immunotherapy.Cells · 2021Review
- International society of sports nutrition position stand: caffeine and exercise performance.Journal of the International Society of Sports Nutrition · 2021Review
- Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells.International journal of molecular sciences · 2020Article
- Precision Medicine in Neonates: Future Perspectives for the Lung.Frontiers in pediatrics · 2020Review
- The Impact of Genetic Variations in ADORA2A in the Association between Caffeine Consumption and Sleep.Genes · 2019Article
- Genetic polymorphisms associated with sleep-related phenotypes; relationships with individual nocturnal symptoms of insomnia in the HUNT study.BMC medical genetics · 2019Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesTo identify common genetic variants that predispose to caffeine-induced insomnia and to test whether genes whose expression changes in the presence of caffeine are enriched for association with caffeine-induced insomnia.
designA hypothesis-free, genome-wide association study.
settingCommunity-based sample of Australian twins from the Australian Twin Registry.
participantsAfter removal of individuals who said that they do not drink coffee, a total of 2,402 individuals from 1,470 families in the Australian Twin Registry provided both phenotype and genotype information. MEASUREMENTS AND
resultsA dichotomized scale based on whether participants reported ever or never experiencing caffeine-induced insomnia. A factor score based on responses to a number of questions regarding normal sleep habits was included as a covariate in the analysis. More than 2 million common single nucleotide polymorphisms (SNPs) were tested for association with caffeine-induced insomnia. No SNPs reached the genome-wide significance threshold. In the analysis that did not include the insomnia factor score as a covariate, the most significant SNP identified was an intronic SNP in the PRIMA1 gene (P = 1.4 × 10⁻⁶, odds ratio = 0.68 [0.53 - 0.89]). An intergenic SNP near the GBP4 gene on chromosome 1 was the most significant upon inclusion of the insomnia factor score into the model (P = 1.9 × 10⁻⁶, odds ratio = 0.70 [0.62 - 0.78]). A previously identified association with a polymorphism in the ADORA2A gene was replicated.
conclusionsSeveral genes have been identified in the study as potentially influencing caffeine-induced insomnia. They will require replication in another sample. The results may have implications for understanding the biologic mechanisms underlying insomnia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.