Evidence map›Paper›PMID 22753905›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2012

Lymphatic mapping and sentinel lymph node biopsy in women with squamous cell carcinoma of the vulva: a gynecologic oncology group study.

Charles F Levenback, Shamshad Ali, Robert L Coleman, Michael A Gold, Jeffrey M Fowler, Patricia L Judson, Maria C Bell, Koen De Geest, Nick M Spirtos, Ronald K Potkul and 7 more

Registry-linked trialOpen access · bronzeAbstract readClinical Trial, Phase IIIMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00003325 (Intraoperative Lymphatic Mapping in Patients With Stage I and II Squamous Carcinoma of the Vulva), which is not on this map. Cited by 109 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 4 pooled it
24.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00003325 phase3completednot on this map

Intraoperative Lymphatic Mapping in Patients With Stage I and II Squamous Carcinoma of the Vulva

TypeinterventionalSponsorGynecologic Oncology GroupRan1999Enrolled515ConditionsVulvar CancerArmsSentinel lymph node mapping
3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 4 syntheses or guidelines pooled it, 387 citations in OpenAlex.

  1. Detection of sentinel lymph node in vulvar cancer usingArchives of gynecology and obstetrics · 2023
    Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Positron Lymphography via IntracervicalJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020
    Trial
  8. Trial
  9. [Vulvar intraepithelial neoplasia and vulvar cancer].Dermatologie (Heidelberg, Germany) · 2026
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Charles F LevenbackDepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Box 440, Houston, TX 77030, USA. clevenba@mdanderson.org
Shamshad Ali
Robert L Coleman
Michael A Gold
Jeffrey M Fowler
Patricia L Judson
Maria C Bell
Koen De Geest
Nick M Spirtos
Ronald K Potkul
Mario M Leitao
Jamie N Bakkum-Gamez
Emma C Rossi
Samuel S Lentz
James J Burke
Linda Van Le
Cornelia L Trimble
Mayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the safety of sentinel lymph node biopsy as a replacement for inguinal femoral lymphadenectomy in selected women with vulvar cancer. PATIENTS AND

methodsEligible women had squamous cell carcinoma, at least 1-mm invasion, and tumor size ≥ 2 cm and ≤ 6 cm. The primary tumor was limited to the vulva, and there were no groin lymph nodes that were clinically suggestive of cancer. All women underwent intraoperative lymphatic mapping, sentinel lymph node biopsy, and inguinal femoral lymphadenectomy. Histologic ultra staging of the sentinel lymph node was prescribed.

resultsIn all, 452 women underwent the planned procedures, and 418 had at least one sentinel lymph node identified. There were 132 node-positive women, including 11 (8.3%) with false-negative nodes. Twenty-three percent of the true-positive patients were detected by immunohistochemical analysis of the sentinel lymph node. The sensitivity was 91.7% (90% lower confidence bound, 86.7%) and the false-negative predictive value (1-negative predictive value) was 3.7% (90% upper confidence bound, 6.1%). In women with tumor less than 4 cm, the false-negative predictive value was 2.0% (90% upper confidence bound, 4.5%).

conclusionSentinel lymph node biopsy is a reasonable alternative to inguinal femoral lymphadenectomy in selected women with squamous cell carcinoma of the vulva.

Indexed as

AgedAged, 80 and overCarcinoma, Squamous CellFemaleGroinHumansIncidenceLymphatic MetastasisLymph Node ExcisionLymph NodesMiddle AgedProspective StudiesSentinel Lymph Node BiopsyVulvar Neoplasms

Identifiers

PMID22753905
PMCPMC3478573
OpenAlexW2139803219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.