Evidence map›Paper›PMID 22753637›Full record

Trial reportPsychosomatic medicine

Predictors of cancer-related pain improvement over time.

Hsiao-Lan Wang, Kurt Kroenke, Jingwei Wu, Wanzhu Tu, Dale Theobald, Susan M Rawl

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00313573 (TeleCare Management of Pain and Depression in Cancer), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00313573 phase3unknown statusnot on this map

TeleCare Management of Pain and Depression in Cancer

TypeinterventionalSponsorIndiana UniversityRan2006Enrolled480ConditionsDepression, Pain, Unspecified Adult Solid Tumor, Protocol SpecificArmsmanagement of therapy complications, pain therapy, psychosocial assessment and care, quality-of-life assessment
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 46 citations in OpenAlex.

  1. Determinants of pain severity changes in ambulatory patients with cancer: an analysis from Eastern Cooperative Oncology Group trial E2Z02.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014
    Trial
  2. Risk factors associated with the co-occurrence of severe pain and sleep disturbance in oncology outpatients receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. The Holistic Approach to Cancer Pain Management.The Ulster medical journal · 2022
    Article
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Longitudinal assessment of pain management with the pain management index in cancer outpatients receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017
    Observational
  13. Article
  14. Article
  15. Article
  16. Psychological and behavioral approaches to cancer pain management.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Hsiao-Lan WangCollege of Nursing, University of South Florida, Tampa, Florida, USA. hwang5@health.usf.edu
Kurt Kroenke
Jingwei Wu
Wanzhu Tu
Dale Theobald
Susan M Rawl
Bridge University · SSUniversity of South Florida · US

Funding

INDIANA UNIVERSITY: TRAINING IN BEHAVIORAL NURSINGT32NR007066 · NINR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI RAWL, SUSAN M · 1990 to 2017
$4.2M
TeleCare Management of Pain and Depression in CancerR01CA115369 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KROENKE, KURT · 2005 to 2009
$2.1M
NCI NIH HHS R01 CA-115369NCI NIH HHS R01 CA115369NINR NIH HHS T32 NR007066
6 · The paper itself

Abstract

objectiveTo determine the predictors of pain improvement among patients being treated for cancer-related pain over 12 months.

methodsA secondary analysis of the telephone care Indiana Cancer Pain and Depression trial was performed. Patients (n = 274) were interviewed at baseline and after 1, 3, 6, and 12 months. Pain improvement outcomes included both a continuous measure (Brief Pain Inventory score) and a categorical measure (pain improved versus pain not improved). Predictor variables included change in depression, age, sex, race, marital status, socioeconomic disadvantage, medical comorbidity, type of cancer, and phase of cancer. Multivariable repeated measures were conducted, adjusting for intervention group assignment, baseline pain severity, and time in months since baseline assessment.

resultsFactors significantly predicting both continuous and categorical pain improvement included participating in the intervention group (β = -0.92, p < .001, odds ratio [OR] = 2.53, 95% confidence interval [CI] = 1.65-3.89), greater improvement in depression (β = -0.31, p = .003, OR = 1.84, 95% CI = 1.35-2.51), higher socioeconomic status (Socioeconomic Disadvantage index; β = 0.25, p = .034; OR = 0.73, 95% CI = 0.56-0.94), and fewer comorbid conditions (β = 0.20, p = .002; OR = 0.84, 95% CI = 0.73-0.96). Patients with more severe pain at baseline or with recurrent or progressive cancer were less likely to experience continuous or categorical pain improvement, respectively.

conclusionsEffective management of depression and comorbid conditions along with improvement of social services could be critical components of a comprehensive pain management. Patients with more severe pain or with recurrent or progressive cancers may require closer monitoring and adequate treatment of pain. Trial Registration clinicaltrials.gov Identifier: NCT00313573.

Indexed as

Models, StatisticalAdultAgedAged, 80 and overDepressive DisorderFemaleHumansLongitudinal StudiesMaleMiddle AgedNeoplasmsOutcome Assessment, Health CarePainPain ManagementPain MeasurementPsychiatric Status Rating Scales

Identifiers

PMID22753637
PMCPMC3392436
OpenAlexW2092788004

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.