Trial reportThe Journal of physiology2012
Human phase response curve to intermittent blue light using a commercially available device.
Trial report in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 72 citations in OpenAlex.
- Trial
- Light Exposure as a Modifiable Determinant of Mental Health.Current psychiatry reports · 2026Review
- Article
- Mathematical Analysis of Light-sensitivity Related Challenges in Assessment of the Intrinsic Period of the Human Circadian Pacemaker.Journal of biological rhythms · 2024Article
- Effects of calibrated blue-yellow changes in light on the human circadian clock.Nature human behaviour · 2024Article
- Entrainment to gradual vs. immediate 8-hour phase advance shifts with and without short-wavelength enriched polychromatic green light.Sleep health · 2024Article
- Effect of Personalized Blue-Enriched White Light Intervention on Rest-Activity and Light Exposure Rhythms in Mild and Moderate Alzheimer's Disease.Psychiatry investigation · 2023Article
- Relationship between Circadian Phase Delay without Morning Light and Phase Advance by Bright Light Exposure the Following Morning.Clocks & sleep · 2023Article
- Light as a Modulator of Non-Image-Forming Brain Functions-Positive and Negative Impacts of Increasing Light Availability.Clocks & sleep · 2023Review
- Stories from a life studying circadian rhythms and sleep.Sleep advances : a journal of the Sleep Research Society · 2023Article
- Human circadian rhythm studies: Practical guidelines for inclusion/exclusion criteria and protocol.Neurobiology of sleep and circadian rhythms · 2022Review
- Article
- Effects of morning and evening exposures to blue light of varying illuminance on ocular growth rates and ocular rhythms in chicks.Experimental eye research · 2022Article
- Earlier chronotype in patients with rheumatoid arthritis.Clinical rheumatology · 2021Article
- Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer's disease.Scientific reports · 2021Article
- Long-Term Narrowband Lighting Influences Activity but Not Intrinsically Photosensitive Retinal Ganglion Cell-Driven Pupil Responses.Frontiers in physiology · 2021Article
- Alerting and Circadian Effects of Short-Wavelength vs. Long-Wavelength Narrow-Bandwidth Light during a Simulated Night Shift.Clocks & sleep · 2020Article
- Estimating Representative Group Intrinsic Circadian Period from Illuminance-Response Curve Data.Journal of biological rhythms · 2020Article
- Blue-Enriched White Light Improves Performance but Not Subjective Alertness and Circadian Adaptation During Three Consecutive Simulated Night Shifts.Frontiers in psychology · 2020Article
- Circadian Responses to Fragmented Light: Research Synopsis in Humans.The Yale journal of biology and medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Light shifts the timing of the circadian clock according to a phase response curve (PRC). To date, all human light PRCs have been to long durations of bright white light. However, melanopsin, the primary photopigment for the circadian system, is most sensitive to short wavelength blue light. Therefore, to optimise light treatment it is important to generate a blue light PRC.We used a small, commercially available blue LED light box, screen size 11.2 × 6.6 cm at ∼50 cm, ∼200 μW cm(−2), ∼185 lux. Subjects participated in two 5 day laboratory sessions 1 week apart. Each session consisted of circadian phase assessments to obtain melatonin profiles before and after 3 days of free-running through an ultradian light–dark cycle (2.5 h wake in dim light, 1.5 h sleep in the dark), forced desynchrony protocol. During one session subjects received intermittent blue light (three 30 min pulses over 2 h) once a day for the 3 days of free-running, and in the other session (control) they remained in dim room light, counterbalanced. The time of blue light was varied among subjects to cover the entire 24 h day. For each individual, the phase shift to blue light was corrected for the free-run determined during the control session. The blue light PRC had a broad advance region starting in the morning and extending through the afternoon. The delay region started a few hours before bedtime and extended through the night. This is the first PRC to be constructed to blue light and to a stimulus that could be used in the real world.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.