ArticleProceedings of the National Academy of Sciences of the United States of America2012
High-throughput single-microparticle imaging flow analyzer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 388 citations in OpenAlex.
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- Imaging flow cytometry with a real-time throughput beyond 1,000,000 events per second.Light, science & applications · 2025Article
- Neuromorphic-enabled video-activated cell sorting.Nature communications · 2024Article
- Review
- Essential Fluidics for a Flow Cytometer.Current protocols · 2024Article
- Lab on a Particle Technologies.Analytical chemistry · 2024Review
- Imaging Flow Cytometry: Development, Present Applications, and Future Challenges.Methods and protocols · 2024Review
- Differential phase-diversity electrooptic modulator for cancellation of fiber dispersion and laser noise.Nature communications · 2023Article
- Inertial focusing of particles and cells in the microfluidic labyrinth device: Role of sharp turns.Biomicrofluidics · 2022Article
- Developments of Conventional and Microfluidic Flow Cytometry Enabling High-Throughput Characterization of Single Cells.Biosensors · 2022Review
- High-speed 3D imaging flow cytometry with optofluidic spatial transformation.Biomedical optics express · 2022Article
- A real-time monitoring system for automatic morphology analysis of yeast cultivation in a jar fermenter.Applied microbiology and biotechnology · 2022Article
- Separation of U87 glioblastoma cell-derived small and medium extracellular vesicles using elasto-inertial flow focusing (a spiral channel).Scientific reports · 2022Article
- Multispectral Imaging Flow Cytometry with Spatially and Spectrally Resolving Snapshot-Mosaic Cameras for the Characterization and Classification of Bioparticles.Micromachines · 2022Article
- High-speed fluorescence image-enabled cell sorting.Science (New York, N.Y.) · 2022Article
- Light sheet based volume flow cytometry (VFC) for rapid volume reconstruction and parameter estimation on the go.Scientific reports · 2022Article
- Towards an engineering theory of evolution.Nature communications · 2021Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
Optical microscopy is one of the most widely used diagnostic methods in scientific, industrial, and biomedical applications. However, while useful for detailed examination of a small number (< 10,000) of microscopic entities, conventional optical microscopy is incapable of statistically relevant screening of large populations (> 100,000,000) with high precision due to its low throughput and limited digital memory size. We present an automated flow-through single-particle optical microscope that overcomes this limitation by performing sensitive blur-free image acquisition and nonstop real-time image-recording and classification of microparticles during high-speed flow. This is made possible by integrating ultrafast optical imaging technology, self-focusing microfluidic technology, optoelectronic communication technology, and information technology. To show the system's utility, we demonstrate high-throughput image-based screening of budding yeast and rare breast cancer cells in blood with an unprecedented throughput of 100,000 particles/s and a record false positive rate of one in a million.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.