ArticleProceedings of the National Academy of Sciences of the United States of America2012
Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Pain-Affective Disorder Comorbidity in the Temporomandibular Disorders: From Mechanistic Insights to Clinical Management.Neuroscience bulletin · 2026Review
- A primary auditory cortex-anterior cingulate cortex circuit underlying cross-modal visceral pain modulation.Nature communications · 2026Article
- Age-related auditory nerve deficits propagate central gain throughout the auditory system: Associations with cortical microstructure and speech recognition.Neurobiology of aging · 2026Article
- Homeostasis of a representational map in the neocortex.Nature neuroscience · 2025Article
- DLX genes and proteins in mammalian forebrain development.Development (Cambridge, England) · 2024Review
- Prefrontal cortical circuits in anxiety and fear: an overview.Frontiers of medicine · 2022Review
- Behavioral Deficits Induced by Somatostatin-Positive GABA Neuron Silencing Are Rescued by Alpha 5 GABA-A Receptor Potentiation.The international journal of neuropsychopharmacology · 2021Article
- Inhibitory interneurons in a brainstem circuit adjust their inhibitory motifs to process multimodal input.The Journal of physiology · 2021Article
- Tinnitus Correlates with Downregulation of Cortical Glutamate Decarboxylase 65 Expression But Not Auditory Cortical Map Reorganization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders.Molecular psychiatry · 2019Review
- Dlx1 and Dlx2 Promote Interneuron GABA Synthesis, Synaptogenesis, and Dendritogenesis.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Prefrontal Cortex GABAergic Deficits and Circuit Dysfunction in the Pathophysiology and Treatment of Chronic Stress and Depression.Current opinion in behavioral sciences · 2017Article
- Central Gain Restores Auditory Processing following Near-Complete Cochlear Denervation.Neuron · 2016Article
- Review
- Glycine receptors control the generation of projection neurons in the developing cerebral cortex.Cell death and differentiation · 2014Article
- Why are cortical GABA neurons relevant to internal focus in depression? A cross-level model linking cellular, biochemical and neural network findings.Molecular psychiatry · 2014Article
- Opposing effects of acute versus chronic blockade of frontal cortex somatostatin-positive inhibitory neurons on behavioral emotionality in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Auditory map plasticity: diversity in causes and consequences.Current opinion in neurobiology · 2014Review
- Bidirectional homeostatic plasticity induced by interneuron cell death and transplantation in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Glycine receptors and brain development.Frontiers in cellular neuroscience · 2013Review
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Abstract
Inhibitory interneurons regulate the responses of cortical circuits. In auditory cortical areas, inhibition from these neurons narrows spectral tuning and shapes response dynamics. Acute disruptions of inhibition expand spectral receptive fields. However, the effects of long-term perturbations of inhibitory circuitry on auditory cortical responses are unknown. We ablated ~30% of dendrite-targeting cortical inhibitory interneurons after the critical period by studying mice with a conditional deletion of Dlx1. Following the loss of interneurons, baseline firing rates rose and tone-evoked responses became less sparse in auditory cortex. However, contrary to acute blockades of inhibition, the sizes of spectral receptive fields were reduced, demonstrating both higher thresholds and narrower bandwidths. Furthermore, long-latency responses at the edge of the receptive field were absent. On the basis of changes in response dynamics, the mechanism for the reduction in receptive field size appears to be a compensatory loss of cortico-cortically (CC) driven responses. Our findings suggest chronic conditions that feature changes in inhibitory circuitry are not likely to be well modeled by acute network manipulations, and compensation may be a critical component of chronic neuronal conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.