ArticleAnnals of the rheumatic diseases2013
Progression of osteoarthritis as a state of inertia.
Article in Annals of the rheumatic diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 5 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 5 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- A systematic review of the association between ultrasound-detected features and laboratory inflammatory biomarkers in hand osteoarthritis.Annals of medicine · 2025Pooled it
- A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis.Annals of the rheumatic diseases · 2023Pooled it
- Defining and predicting radiographic knee osteoarthritis progression: a systematic review of findings from the osteoarthritis initiative.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Pooled it
- Identification of pain categories associated with change in pain in patients receiving placebo: data from two phase 3 randomized clinical trials in symptomatic knee osteoarthritis.BMC musculoskeletal disorders · 2018Pooled it
- A replication study and meta-analysis of mitochondrial DNA variants in the radiographic progression of knee osteoarthritis.Rheumatology (Oxford, England) · 2017Pooled it
- Trial
- Accurate classification and prediction of knee osteoarthritis based on Al-Biruni Earth Radius metaheuristic optimizer and LSTM classifier.Scientific reports · 2026Article
- Borderline acceleration in blood epigenetic age of unclear biological importance in knee osteoarthritis progression: Specimens and data from the Osteoarthritis Initiative and Johnston County Osteoarthritis Project.Osteoarthritis and cartilage · 2026Article
- Article
- ZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis.Nature aging · 2025Article
- MonitOring the health trajectory of patients with kNee osteoarthritis referred for orthopaedic opinion: Protocol for the MOTION parallel cohort-implementation study.Osteoarthritis and cartilage open · 2025Article
- Osteoarthritis: Magnetic resonance imaging definitions and disease progression: comment on the article by Chang et al.Arthritis & rheumatology (Hoboken, N.J.) · 2025Article
- To What Degree Do Patients' and Clinicians' Ratings of Appropriateness of TKA Align, and Were Expected Outcomes Associated With Those Ratings?Clinical orthopaedics and related research · 2025Article
- Do Existing Magnetic Resonance Imaging Definitions of Knee Osteoarthritis Identify Knees That Will Develop Clinically Significant Disease Over Up To 11 Years of Follow-Up?Arthritis & rheumatology (Hoboken, N.J.) · 2025Article
- Article
- Severity and progression of structural hand OA is not associated with progression of structural knee OA: The IMI-APPROACH cohort.Osteoarthritis and cartilage open · 2024Article
- An interpretable knee replacement risk assessment system for osteoarthritis patients.Osteoarthritis and cartilage open · 2024Article
- Timing is everything: Towards classification criteria for early-stage symptomatic knee osteoarthritis.Osteoarthritis and cartilage · 2024Article
- Molecular Mechanisms Linking Osteoarthritis and Alzheimer's Disease: Shared Pathways, Mechanisms and Breakthrough Prospects.International journal of molecular sciences · 2024Review
- Structural phenotypes of knee osteoarthritis: potential clinical and research relevance.Skeletal radiology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo test whether knees which recently developed disease were at higher risk for subsequent x-ray progression than knees which had been stable, suggesting that recent change produces further change and recent stability yields subsequent stability (a pattern of inertia).
methodsWe used central readings of the annual posteroanterior x-rays obtained in the Osteoarthritis Initiative (OAI) focusing on change in Kellgren and Lawrence (KL) grade and change in semiquantitative joint space. We examined whether knees that had developed incident disease (KL grade 2) were at higher risk of subsequent progression than knees that were already grade 2 and had had stable disease. We combined data from multiple examinations. Using generalised estimating equations to adjust for the correlation between knees, we carried out logistic regression evaluating the risk for disease progression testing incident versus stable disease adjusting for age, sex, body mass index, physical activity, quadriceps strength and mechanical alignment.
results1562 OAI subjects with grade 2 disease had a mean age of 61.8 years, mean BMI of 29.4, and 61.7% were women. Of knees with stable disease, 4.1% showed progression within the next 12 months in KL grade versus 13.7% in those with incident disease (adjusted OR 4.0; 95% CI 2.4 to 6.7). For progression of joint space loss, we found a similar relation with incident versus stable disease (adjusted OR 5.3; 95% CI 3.6 to 7.9).
conclusionsKnee osteoarthritis radiographic progression follows a pattern of inertia. Factors that trigger the transition from stable disease to progression should be sought.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.