ArticleActa neuropathologica1990
Glucocorticoid therapy obscures the diagnosis of cerebral lymphoma.
Article in Acta neuropathologica, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guidelines for diagnosis, prevention and management of central nervous system involvement in diffuse large B-cell lymphoma patients by the Spanish Lymphoma Group (GELTAMO).Haematologica · 2017Guideline
- Analysis of False-negative Findings of the Incomparable Accuracy and Swiftness of Flow Cytometric Diagnosis of Primary Central Nervous System Lymphoma.Neurologia medico-chirurgica · 2023Article
- Evidence-based expert consensus on the management of primary central nervous system lymphoma in China.Journal of hematology & oncology · 2022Review
- Primary Central Nervous System Lymphomas: A Diagnostic Overview of Key Histomorphologic, Immunophenotypic, and Genetic Features.Diagnostics (Basel, Switzerland) · 2020Review
- Efficacy of a Second Brain Biopsy for Intracranial Lesions after Initial Negativity.Journal of clinical neurology (Seoul, Korea) · 2020Article
- The Impact of Early Corticosteroid Pretreatment Before Initiation of Chemotherapy in Patients With Primary Central Nervous System Lymphoma.Neurosurgery · 2019Observational
- Diagnostic red flags: steroid-treated malignant CNS lymphoma mimicking autoimmune inflammatory demyelination.Brain pathology (Zurich, Switzerland) · 2018Article
- The Combined Performance of ADC, CSF CXC Chemokine Ligand 13, and CSF Interleukin 10 in the Diagnosis of Central Nervous System Lymphoma.AJNR. American journal of neuroradiology · 2016Article
- Performance of Apparent Diffusion Coefficient Values and Conventional MRI Features in Differentiating Tumefactive Demyelinating Lesions From Primary Brain Neoplasms.AJR. American journal of roentgenology · 2015Article
- Primary central nervous system lymphoma: is absence of intratumoral hemorrhage a characteristic finding on MRI?Radiology and oncology · 2015Article
- A systematic approach to the diagnosis of suspected central nervous system lymphoma.JAMA neurology · 2013Review
- Glioblastoma presenting with steroid-induced pseudoregression of contrast enhancement on magnetic resonance imaging.Case reports in neurological medicine · 2012Article
- Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma: effect of prior corticosteroid therapy.Virchows Archiv : an international journal of pathology · 2009Article
- Diagnosis of inflammatory demyelination in biopsy specimens: a practical approach.Acta neuropathologica · 2008Review
- Atypical manifestation of childhood primary cerebral lymphoma restricted to the leptomeninges.European journal of pediatrics · 2005Article
- [Diagnosis of an initial infratentorial central nervous system B-cell lymphoma during prolonged cortisone medication].Der Nervenarzt · 2004Article
- Intracranial inflammatory tumors: a survey of their various etiologies by presentation of 5 cases.Journal of neuro-oncology · 1999Article
- Primary central nervous system lymphoma: from clinical presentation to diagnosis.Journal of neuro-oncology · 1999Review
- Glucocorticoid treatment of primary CNS lymphoma.Journal of neuro-oncology · 1999Review
- Glucocorticoid-induced long-term remission in primary cerebral lymphoma: case report and review of the literature.Journal of neuro-oncology · 1997Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropathological and radiographical findings of two patients with primary CNS B cell lymphoma are presented. Prior to computerized tomographic (CT)-guided stereotactic biopsy both patients had received glucocorticoid therapy which led to marked tumor regression on CT scans and transient improvement of neurological deficits. Despite careful targeting and serial sampling, multiple biopsy specimens examined cytologically, histologically and immunomorphologically showed nonspecific reactive astrogliosis and conspicuous perivascular infiltrates of T lymphocytes. A second biopsy performed after an interval of 2 and 8 weeks, respectively, and short-term discontinuation of dexamethasone therapy in one case, unequivocally established the diagnosis of Non-Hodgkin lymphoma. It is concluded that steroid therapy may obscure the bioptic diagnosis of cerebral lymphoma. In addition to the well-known antiedematous effect of glucocorticoids neuropathologists and neurosurgeons should be aware of a rapid and pronounced lymphodepletive action of steroids on malignant CNS lymphomas.
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Registered trials
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