ArticleInfection and immunity2012
Dissemination bottleneck in a murine model of inhalational anthrax.
Article in Infection and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Inducible transposon mutagenesis identifies bacterial fitness determinants during infection in mice.Nature microbiology · 2025Article
- Characterization of Lactobacilli Phage Endolysins and Their Functional Domains-Potential Live Biotherapeutic Testing Reagents.Viruses · 2023Article
- Clonal population expansion of Staphylococcus aureus occurs due to escape from a finite number of intraphagocyte niches.Scientific reports · 2023Article
- Commensal bacteria augment Staphylococcus aureus infection by inactivation of phagocyte-derived reactive oxygen species.PLoS pathogens · 2021Article
- The Role of Macrophages inFrontiers in immunology · 2020Review
- Integrating mathematical models with experimental data to investigate the within-host dynamics of bacterial infections.Pathogens and disease · 2019Review
- Article
- Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection.Cell reports · 2016Article
- Surviving Between Hosts: Sporulation and Transmission.Microbiology spectrum · 2016Review
- Making pathogens sociable: the [corrected] emergence of high relatedness through limited host invasibility.The ISME journal · 2015Article
- New insights into how Yersinia pestis adapts to its mammalian host during bubonic plague.PLoS pathogens · 2014Article
- Clonal expansion during Staphylococcus aureus infection dynamics reveals the effect of antibiotic intervention.PLoS pathogens · 2014Article
- In trans complementation of lethal factor reveal roles in colonization and dissemination in a murine mouse model.PloS one · 2014Article
- Bacillus anthracis has two independent bottlenecks that are dependent on the portal of entry in an intranasal model of inhalational infection.Infection and immunity · 2013Article
- Protective-antigen (PA) based anthrax vaccines confer protection against inhalation anthrax by precluding the establishment of a systemic infection.Human vaccines & immunotherapeutics · 2013Article
- Pathoadaptive mutations in Salmonella enterica isolated after serial passage in mice.PloS one · 2013Article
- A New Murine Model for Gastrointestinal Anthrax Infection.PloS one · 2013Article
- A single-dose PLGA encapsulated protective antigen domain 4 nanoformulation protects mice against Bacillus anthracis spore challenge.PloS one · 2013Article
- Killing bacterial spores with blue light: when innate resistance meets the power of light.Photochemistry and photobiologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Inhalational anthrax is caused by the sporulating bacterium Bacillus anthracis. A current model for progression in mammalian hosts includes inhalation of bacterial spores, phagocytosis of spores in the nasal mucosa-associated lymphoid tissue (NALT) and lungs by macrophages and dendritic cells, trafficking of phagocytes to draining lymph nodes, germination of spores and multiplication of vegetative bacteria in the NALT and lymph nodes, and dissemination of bacteria via the bloodstream to multiple organs. In previous studies, the kinetics of infection varied greatly among mice, leading us to hypothesize the existence of a bottleneck past which very few spores (perhaps only one) progress to allow the infection to proceed. To test this hypothesis, we engineered three strains of B. anthracis Sterne, each marked with a different fluorescent protein, enabling visual differentiation of strains grown on plates. Mice were infected with a mixture of the three strains, the infection was allowed to proceed, and the strains colonizing the organs were identified. Although the inoculum consisted of approximately equal numbers of each of the three strains, the distal organs were consistently colonized by a majority of only one of the three strains, with the dominant strain varying among animals. Such dominance of one strain over the other two was also found at early time points in the cervical lymph nodes but not in the mediastinal lymph nodes. These results support the existence of a bottleneck in the infectious process.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.