ArticlePharmaceutical research2012
Simulating intravitreal injections in anatomically accurate models for rabbit, monkey, and human eyes.
Article in Pharmaceutical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Molecular Determinants of Intravitreal Anti-VEGF Durability: Drug Architecture, Intraocular Pharmacokinetics, Target Biology and Treatment Resistance.International journal of molecular sciences · 2026Review
- Applications of Thermoresponsive Hydrogels for Sustained Drug Release in Ocular and Intravitreal Formulations Treating Visual Impairments.The AAPS journal · 2026Review
- Injected Eye, Fellow Eye and Systemic Pharmacokinetic Modeling of Intravitreally Administered Bevacizumab.Molecular pharmaceutics · 2026Article
- Pharmacokinetic model for drug delivery by Ozurdex.Drug delivery and translational research · 2026Article
- Effect of Molecular Size on Ocular Drug Distribution After Intravitreal Injection Using Computed Tomography and Mathematical Spatial Modeling.Pharmaceutical research · 2025Article
- Novel Pharmacokinetic Bridging Strategy for Locally Acting Intravitreal Drug Products.The AAPS journal · 2025Article
- Mathematical Models of Topically and Intravitreally Applied Ranibizumab.Investigative ophthalmology & visual science · 2025Article
- Ultrastructural and Immunohistochemical Study of Double and Combined Intravitreal Administration of Antifungal Agents in the Retina of New Zealand Albino Rabbits: An Experimental Protocol.Journal of fungi (Basel, Switzerland) · 2025Article
- Modeling the Ocular Pharmacokinetics and Pharmacodynamics of Ranibizumab for Improved Understanding and Data Collection Strategies in Ocular Diseases.Investigative ophthalmology & visual science · 2025Article
- Intravitreal Administration of Avacincaptad Pegol in a Nonhuman Primate Model of Dry Age-Related Macular Degeneration.Pharmacology research & perspectives · 2025Article
- Computer modeling of bevacizumab drug distribution after intravitreal injection in rabbit and human eyes.Journal of pharmaceutical sciences · 2025Article
- Translational physiologically-based pharmacokinetic model for ocular disposition of monoclonal antibodies.Journal of pharmacokinetics and pharmacodynamics · 2024Article
- A First-Passage Model of Intravitreal Drug Delivery and Residence Time-Influence of Ocular Geometry, Individual Variability, and Injection Location.Investigative ophthalmology & visual science · 2024Article
- Mathematical Models of Ocular Drug Delivery.Investigative ophthalmology & visual science · 2024Review
- Multi-physics simulations for investigating the effect of electrode conditions on transscleral ocular iontophoresis for particulate drug delivery into ocular tissues.Biomedical engineering letters · 2024Article
- Drug Distribution After Intravitreal Injection: A Mathematical Model.Investigative ophthalmology & visual science · 2024Article
- Experimental and mathematical approaches for drug delivery for the treatment of wet age-related macular degeneration.Journal of controlled release : official journal of the Controlled Release Society · 2023Review
- A Physiology-Based Mathematical Model to Understand Drug Delivery from Contact Lenses to the Back of the Eye.Pharmaceutical research · 2023Article
- International consortium for innovation and quality: An industry perspective on the nonclinical and early clinical development of intravitreal drugs.Clinical and translational science · 2023Article
- Computational Model of In Vivo Corneal Pharmacokinetics and Pharmacodynamics of Topically Administered Ophthalmic Drug Products.Pharmaceutical research · 2023Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo develop models for rabbit, monkey, and human that enable prediction of the clearance after intravitreal (IVT) injections in one species from experimental results obtained in another species.
methodsAnatomically accurate geometric models were constructed for rabbit, monkey, and human that enabled computational fluid dynamic simulation of clearance of an IVT injected bolus. Models were constructed with and without the retrozonular space of Petit. Literature data on clearance after IVT injection of substances spanning a range of molecular weight up to 157 kDa were used to validate the rabbit model.
resultsThe space of Petit had a significant increase on the clearance of slowly diffusing substances cleared by the anterior pathway by reducing the bottleneck for drug efflux. Models that did not include this zone could not accurately predict the clearance of slowly diffusing substances whose clearance was accelerated by intraocular pressure-driven convection.
conclusionsThe ocular anatomy must be carefully reconstructed in the model to enable accurate predictions of clearance. This method offers an alternative means for scaling experimental data from one species to another that may be more appropriate than other simple approaches based entirely upon scaling of compartment volumes and flow rates.
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