ArticleInternational journal of legal medicine2012
Combining results of forensic STR kits: HDplex validation including allelic association and linkage testing with NGM and Identifiler loci.
Article in International journal of legal medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 47 citations in OpenAlex.
- Swedish population data for 37 autosomal, 12 X-chromosomal and 23 Y-chromosomal STR loci.International journal of legal medicine · 2026Article
- Beyond the Core: The Role of Supplementary Short Tandem Repeats in Forensic Genetics.International journal of molecular sciences · 2026Review
- USP24 is a cross-reactive DUB targeting MOV10 to regulate IFN-I production.Nature communications · 2026Article
- Identification of a large off-ladder allele of the D21S2055 locus during population genetics analysis.International journal of legal medicine · 2026Article
- Evaluation and SNP typing of DNA from ultraviolet-irradiated human bloodstains using TaqMan assay.Scientific reports · 2021Article
- The Heart of Silk Road "Xinjiang," Its Genetic Portray, and Forensic Parameters Inferred From Autosomal STRs.Frontiers in genetics · 2021Article
- An evaluation of the SureID 23comp Human Identification Kit for kinship testing.Scientific reports · 2019Article
- Genetic polymorphism and phylogenetic differentiation of the Huaxia Platinum System in three Chinese minority ethnicities.Scientific reports · 2019Article
- Genetic polymorphism of 29 STR loci in the Hunan Han population from China.Forensic sciences research · 2019Article
- Population genetic data of Investigator HDplex markers in Han population from Southern China.International journal of legal medicine · 2019Article
- Population Genetic Analysis of Modern and Ancient DNA Variations Yields New Insights Into the Formation, Genetic Structure, and Phylogenetic Relationship of Northern Han Chinese.Frontiers in genetics · 2019Article
- Evaluation of forensic genetic parameters of 12 STR loci in the Korean population using the InvestigatorInternational journal of legal medicine · 2017Article
- Kinship analysis: assessment of related vs unrelated based on defined pedigrees.International journal of legal medicine · 2016Article
- Investigator HDplex markers: allele frequencies and mutational events in a North Italian population.International journal of legal medicine · 2015Article
- Genetic polymorphism of the 26 short tandem repeat loci in the Chinese Hebei Han population using two commercial forensic kits.Molecular biology reports · 2015Article
- Analysis of linkage and linkage disequilibrium for syntenic STRs on 12 chromosomes.International journal of legal medicine · 2014Article
- Evaluation of genetic parameters of 22 autosomal STR loci (PowerPlex® Fusion System) in a population sample from Northern Italy.International journal of legal medicine · 2014Article
- Assessment of application value of 19 autosomal short tandem repeat loci of GoldenEye 20A kit in forensic paternity testing.International journal of legal medicine · 2013Article
- Substitution mutation induced migration anomaly of a D10S2325 allele on capillary electrophoresis.International journal of legal medicine · 2013Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The autosomal short tandem repeat (STR) kits that are currently used in forensic science have a high discrimination power. However, this discrimination power is sometimes not sufficient for complex kinship analyses or decreases when alleles are missing due to degradation of the DNA. The Investigator HDplex kit contains nine STRs that are additional to the commonly used forensic markers, and we validated this kit to assist human identification. With the increasing number of markers it becomes inevitable that forensic and kinship analyses include two or more STRs present on the same chromosome. To examine whether such markers can be regarded as independent, we evaluated the 30 STRs present in NGM, Identifiler and HDplex. Among these 30 markers, 17 syntenic STR pairs can be formed. Allelic association between these pairs was examined using 335 Dutch reference samples and no linkage disequilibrium was detected, which makes it possible to use the product rule for profile probability calculations in unrelated individuals. Linkage between syntenic STRs was studied by determining the recombination fraction between them in five three-generation CEPH families. The recombination fractions were compared to the physical and genetic distances between the markers. For most types of pedigrees, the kinship analyses can be performed using the product rule, and for those cases that require an alternative calculation method (Gill et al., Forensic Sci Int Genet 6:477-486, 2011), the recombination fractions as determined in this study can be used. Finally, we calculated the (combined) match probabilities, for the supplementary genotyping results of HDplex, NGM and Identifiler.
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