ArticleInternational journal of legal medicine2012
Molecular pathology of natriuretic peptides in the myocardium with special regard to fatal intoxication, hypothermia, and hyperthermia.
Article in International journal of legal medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Immunohistochemical insights into hyperthermia-related deaths: a systematic review.International journal of legal medicine · 2025Pooled it
- Immunohistochemical insights into hypothermia-related deaths: a systematic review.Forensic science, medicine, and pathology · 2025Pooled it
- Article
- Cortisol levels after cold exposure are independent of adrenocorticotropic hormone stimulation.PloS one · 2020Article
- Combined determination of B-type natriuretic peptide and high-sensitivity troponin I in the postmortem diagnosis of cardiac disease.Forensic science, medicine, and pathology · 2019Article
- The Expression of BNP, ET-1, and TGF-β1 in Myocardium of Rats with Ventricular Arrhythmias.International journal of molecular sciences · 2019Article
- BNP and NT-proBNP as Diagnostic Biomarkers for Cardiac Dysfunction in Both Clinical and Forensic Medicine.International journal of molecular sciences · 2019Review
- Differential expression of B-type natriuretic peptide between left and right ventricles, with particular regard to sudden cardiac death.Molecular medicine reports · 2017Article
- Hypothermia provokes hemorrhaging in various core muscle groups: how many of them could we have missed?International journal of legal medicine · 2017Article
- Decreased mRNA levels of cardiac Cx43 and ZO1 in sudden cardiac death related to coronary atherosclerosis: a pilot study.International journal of legal medicine · 2016Article
- Postmortem diagnosis of hypothermia.International journal of legal medicine · 2014Review
- Molecular pathology of brain matrix metalloproteases, claudin5, and aquaporins in forensic autopsy cases with special regard to methamphetamine intoxication.International journal of legal medicine · 2014Article
- Article
- Molecular pathology of brain edema after severe burns in forensic autopsy cases with special regard to the importance of reference gene selection.International journal of legal medicine · 2013Article
- Stability of endogenous reference genes in postmortem human brains for normalization of quantitative real-time PCR data: comprehensive evaluation using geNorm, NormFinder, and BestKeeper.International journal of legal medicine · 2012Article
- Molecular pathology of pulmonary edema after injury in forensic autopsy cases.International journal of legal medicine · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigated the molecular pathology of atrial and brain natriuretic peptides (ANP and BNP) in the myocardium to evaluate terminal cardiac function in routine forensic casework with particular regard to fatal drug intoxication (n = 18; sedative-hypnotics, n = 10; methamphetamine, n = 8), hypothermia (cold exposure, n = 13), and hyperthermia (heatstroke, n = 10), compared with that in acute ischemic heart disease (AIHD, n = 35) and congestive heart disease (CHD, n = 11) as controls (total n = 87; within 48 h postmortem). Quantitative analyses of myocardial ANP and BNP messenger RNA demonstrated that their expressions in bilateral atrial and ventricular walls were high in methamphetamine intoxication and hypothermia, comparable to those in AIHD and CHD, but were low in sedative-hypnotic intoxication and hyperthermia. In pericardial fluid, both ANP and BNP levels were increased in hypothermia, while CHD cases had an elevated BNP level, and ANP level showed a tendency to increase in hyperthermia; however, immunohistochemistry showed no evident differences in myocardial ANP and BNP among the causes of death. These findings suggest terminal high cardiac strain in methamphetamine intoxication, decreased cardiac strain in sedative-hypnotic intoxication and hyperthermia (heatstroke), and persistent congestion in hypothermia (cold exposure).
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