ReviewMolecular neurobiology2012
Driving apoptosis-relevant proteins toward neural differentiation.
Review in Molecular neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- A Novel Small Molecule p53 Stabilizer for Brain Cell Differentiation.Frontiers in chemistry · 2019Article
- Scutellarin may alleviate cognitive deficits in a mouse model of hypoxia by promoting proliferation and neuronal differentiation of neural stem cells.Iranian journal of basic medical sciences · 2017Article
- Surviving apoptosis: life-death signaling in single cells.Trends in cell biology · 2015Review
- Susceptibility of murine induced pluripotent stem cell-derived cardiomyocytes to hypoxia and nutrient deprivation.Stem cell research & therapy · 2015Article
- Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism.Journal of neuroinflammation · 2015Article
- Expression of p53 target genes in the early phase of long-term potentiation in the rat hippocampal CA1 area.Neural plasticity · 2015Article
- MicroRNA-34a Modulates Neural Stem Cell Differentiation by Regulating Expression of Synaptic and Autophagic Proteins.Molecular neurobiology · 2015Article
- Mitochondrial translocation of p53 modulates neuronal fate by preventing differentiation-induced mitochondrial stress.Antioxidants & redox signaling · 2014Article
- The dual behavior of PCSK9 in the regulation of apoptosis is crucial in Alzheimer's disease progression (Review).Biomedical reports · 2014Article
- Tauroursodeoxycholic acid increases neural stem cell pool and neuronal conversion by regulating mitochondria-cell cycle retrograde signaling.Cell cycle (Georgetown, Tex.) · 2014Article
- Synthetic condensed 1,4-naphthoquinone derivative shifts neural stem cell differentiation by regulating redox state.Molecular neurobiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging evidence suggests that apoptosis regulators and executioners may control cell fate, without involving cell death per se. Indeed, several conserved elements of apoptosis are integral components of terminal differentiation, which must be restrictively activated to assure differentiation efficiency, and carefully regulated to avoid cell loss. A better understanding of the molecular mechanisms underlying key checkpoints responsible for neural differentiation, as an alternative to cell death will surely make stem cells more suitable for neuro-replacement therapies. In this review, we summarize recent studies on the mechanisms underlying the non-apoptotic function of p53, caspases, and Bcl-2 family members during neural differentiation. In addition, we discuss how apoptosis-regulatory proteins control the decision between differentiation, self-renewal, and cell death in neural stem cells, and how activity is restrained to prevent cell loss.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.