Evidence map›Paper›PMID 22752632›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2012

Apelin-13 increases myocardial progenitor cells and improves repair postmyocardial infarction.

Lanfang Li, Heng Zeng, Jian-Xiong Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 129 citations in OpenAlex.

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  16. The Yin and Yang Effect of the Apelinergic System in Oxidative Stress.International journal of molecular sciences · 2023
    Review
  17. Review
  18. A Review of the Roles of Apelin and ELABELA Peptide Ligands in Cardiovascular Disease, Including Heart Failure and Hypertension.Medical science monitor : international medical journal of experimental and clinical research · 2022
    Review
  19. Article
  20. A network map of apelin-mediated signaling.Journal of cell communication and signaling · 2022
    Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lanfang LiDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
Heng Zeng
Jian-Xiong Chen
University of Mississippi Medical Center · US

Funding

Regulation of vascular maturation/regression in diabetesR01HL102042 · NHLBI · VANDERBILT UNIVERSITY · PI CHEN, JIAN-XIONG · 2010 to 2020
$3.0M
NHLBI NIH HHS HL-102042NHLBI NIH HHS R01 HL102042
6 · The paper itself

Abstract

Apelin is an endogenous ligand for the angiotensin-like 1 receptor (APJ) and has beneficial effects against myocardial ischemia-reperfusion injury. Little is known about the role of apelin in the homing of vascular progenitor cells (PCs) and cardiac functional recovery postmyocardial infarction (post-MI). The present study investigated whether apelin affects PC homing to the infarcted myocardium, thereby mediating repair and functional recovery post-MI. Mice were infarcted by coronary artery ligation, and apelin-13 (1 mg·kg(-1)·day(-1)) was injected for 3 days before MI and for 14 days post-MI. Homing of vascular PCs [CD133(+)/c-Kit(+)/Sca1(+), CD133(+)/stromal cell-derived factor (SDF)-1α(+), and CD133(+)/CXC chemokine receptor (CXCR)-4(+)] into the ischemic area was examined. Myocardial Akt, endothelial nitric oxide synthase (eNOS), VEGF, jagged1, notch3, SDF-1α, and CXCR-4 expression were assessed at 24 h and 14 days post-MI. Functional analyses were performed on day 14 post-MI. Mice that received apelin-13 treatment demonstrated upregulation of SDF-1α/CXCR-4 expression and dramatically increased the number of CD133(+)/c-Kit(+)/Sca1(+), CD133(+)/SDF-1α(+), and c-Kit(+)/CXCR-4(+) cells in infarcted hearts. Apelin-13 also significantly increased Akt and eNOS phosphorylation and upregulated VEGF, jagged1, and notch3 expression in ischemic hearts. This was accompanied by a significant reduction of myocardial apoptosis. Furthermore, treatment with apelin-13 promoted myocardial angiogenesis and attenuated cardiac fibrosis and hypertrophy together with a significant improvement of cardiac function at 14 days post-MI. Apelin-13 increases angiogenesis and improves cardiac repair post-MI by a mechanism involving the upregulation of SDF-1α/CXCR-4 and homing of vascular PCs.

Indexed as

AC133 AntigenAdipokinesAnimalsAntigens, CDAntigens, LyApelinApoptosisBiomarkersCalcium-Binding ProteinsCardiomegalyCardiotonic AgentsCell MovementCells, CulturedChemokine CXCL12Disease Models, AnimalFibrosisAC133 AntigenAdipokinesAntigens, CDAntigens, LyApelinapelin-13 peptideApln protein, mouseBiomarkersCalcium-Binding ProteinsCardiotonic AgentsChemokine CXCL12Cxcl12 protein, mouseCXCR4 protein, mouseGlycoproteinsIntercellular Signaling Peptides and ProteinsJag1 protein, mouseJagged-1 ProteinLy6a protein, mouseMembrane ProteinsNitric Oxide Synthase Type IIINos3 protein, mouseNotch3 protein, mousePeptidesProm1 protein, mouseProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-kitReceptor, Notch3Receptors, CXCR4Receptors, NotchSerrate-Jagged ProteinsVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouse

Identifiers

PMID22752632
PMCPMC3468469
OpenAlexW2078239070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.