ArticleHuman reproduction (Oxford, England)2012
A decrease in serum estradiol levels after human chorionic gonadotrophin administration predicts significantly lower clinical pregnancy and live birth rates in in vitro fertilization cycles.
Article in Human reproduction (Oxford, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Associations of pregnancies and livebirths with postmenopausal osteoporosis odds and modifying effects of physical activity.BMC public health · 2026Article
- Association Between Post-Trigger Hormones andJournal of clinical gynecology and obstetrics · 2026Article
- Magnitude of Post-Retrieval Estradiol Decline Directly Compromises Clinical Pregnancy and Live Birth Rates in High Responders Undergoing IVF/ICSI cycles with antagonist protocols.Journal of assisted reproduction and genetics · 2026Article
- Association of estradiol and progesterone levels on human chorionic gonadotropin day with pregnancy outcomes in IVF/ICSI fresh embryo transfer.Frontiers in endocrinology · 2026Article
- Non-Linear Association Between Serum Estradiol Decline and Clinical Outcomes in IVF/ICSI Cycles: A Retrospective Cohort Study.International journal of women's health · 2026Article
- A valuable predictive model for optimizing the timing of oocyte retrieval: a retrospective analysis of oocyte retrieval time in 49,961 oocyte pickup (OPU) cycles.Reproductive biology and endocrinology : RB&E · 2025Article
- Impact of relative estradiol changes during ovarian stimulation on blastocyst formation and live birth in assisted reproductive technology.Scientific reports · 2025Article
- Peri-implantation estradiol level has no effect on pregnancy outcome in vitro fertilization- embryo transfer.Frontiers in endocrinology · 2024Article
- Serum and follicular fluid metabolome and markers of ovarian stimulation.Human reproduction (Oxford, England) · 2023Article
- The pathophysiological role of estrogens in the initial stages of pregnancy: molecular mechanisms and clinical implications for pregnancy outcome from the periconceptional period to end of the first trimester.Human reproduction update · 2023Review
- Serum estradiol level on the day of trigger as a predictor of number of metaphase II oocytes from IVF antagonist cycles and subsequent impact on pregnancy rates.JBRA assisted reproduction · 2021Observational
- The effect of blastomere loss during frozen embryo transfer on the transcriptome of offspring's umbilical cord blood.Molecular biology reports · 2020Article
- Clinical and genetic analysis of cytochrome P450 oxidoreductase (POR) deficiency in a female and the analysis of a novel POR intron mutation causing alternative mRNA splicing : Overall analysis of a female with POR deficiency.Journal of assisted reproduction and genetics · 2020Article
- Detection of T lymphocyte subsets and related functional molecules in follicular fluid of patients with polycystic ovary syndrome.Scientific reports · 2019Article
- A Higher Estradiol Rise After Dual Trigger in Progestin-Primed Ovarian Stimulation Is Associated With a Lower Oocyte and Mature Oocyte Yield in Normal Responders.Frontiers in endocrinology · 2019Article
- Decrease in preovulatory serum estradiol is a valuable marker for predicting premature ovulation in natural/unstimulated in vitro fertilization cycle.Journal of ovarian research · 2018Article
- Influence of body mass index and polycystic ovarian syndrome on ICSI/IVF treatment outcomes: A study conducted in Pakistani women.International journal of reproductive biomedicine · 2018Article
- Outcomes of neonates born following transfers of frozen-thawed cleavage-stage embryos with blastomere loss: a prospective, multicenter, cohort study.BMC medicine · 2018Article
- Outcome Analysis of Day-3 Frozen Embryo Transfer v/s Fresh Embryo Transfer in Infertility: A Prospective Therapeutic Study in Indian Scenario.Journal of obstetrics and gynaecology of India · 2016Article
- The relationship between estradiol-progesterone alterations after ovulation trigger and treatment success in intrauterine insemination cycles.Turkish journal of obstetrics and gynecology · 2016Article
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4 authors.
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Abstract
backgroundAlthough close observation of serum estradiol (E2) levels remains a mainstay of assessing clinical response to controlled ovarian stimulation, the prognostic value of any change in E2 levels after administration of hCG remains unclear. The objective of this study is to evaluate the relationship between serum E2 response after hCG administration and the clinical pregnancy and live birth rates in fresh IVF cycles.
methodsWe conducted a retrospective cohort study of women aged 21-45 years undergoing their first IVF cycle from 1999 to 2008 at a single practice. We compared the post-hCG serum E2 level with values on the day of hCG trigger. IVF cycles were stratified by post-hCG E2 response and appropriate parametric and non-parametric statistics were performed. Clinical intrauterine pregnancy and live births were the primary outcomes of interest. Multivariable logistic regression models were created to identify predictive factors associated with outcomes while adjusting for potential confounders.
resultsAmong the 1712 IVF cycles, 1065 exhibited a >10% increase (Group A), 525 had a plateau (± 10%, Group B) and 122 showed a >10% decrease (Group C) in post-hCG E2 levels. While the E2 levels on the day of hCG were similar across groups, Group C had more patients with diminished ovarian reserve, required higher gonadotrophin doses and had the lowest implantation rates. After adjusting for age, total gonadotrophin dose, infertility diagnosis, number of oocytes and number of transferred embryos, the associations between post-hCG E2 decline (Group C) and clinical pregnancy [adjusted odds ratio (aOR): 0.53; 95% confidence interval (CI): 0.33-0.84, P= 0.007] and live birth (aOR: 0.40; 95% CI: 0.22-0.71, P= 0.002) were significant. We also found significant associations between E2 plateau (Group B) and clinical pregnancy (aOR: 0.73; 95% CI: 0.57-0.94, P= 0.013) and live birth (aOR: 0.74; 95% CI: 0.56-0.97, P= 0.032) when adjusting for the same factors.
conclusionsIn our study, >10% decrease in E2 levels after hCG administration was associated with 40-50% reduction in clinical pregnancy and live birth rates. Similarly, post-hCG E2 plateau (± 10%) lowered the clinical pregnancy and live birth rates by >25%. Our study suggests that the change in the post-hCG E2 level is another parameter that can be used by clinicians to counsel patients regarding their likelihood of success with assisted reproductive technologies prior to oocyte retrieval.
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