ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2012
Diagnosis, clinical presentation, and in-hospital mortality of severe malaria in HIV-coinfected children and adults in Mozambique.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.
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21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Burden of malaria-HIV coinfection and associated adverse outcomes in Ethiopia: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Unraveling the HIV-malaria interactions: a bibliometric analysis of global research trends and emerging insights.Frontiers in microbiology · 2025Pooled it
- A meta-analysis on the prevalence and characteristics of severe malaria in patients with Plasmodium spp. and HIV co-infection.Scientific reports · 2021Pooled it
- Clinical and laboratory predictors of death in African children with features of severe malaria: a systematic review and meta-analysis.BMC medicine · 2017Pooled it
- Pooled it
- Economic evaluation of an alternative drug to sulfadoxine-pyrimethamine as intermittent preventive treatment of malaria in pregnancy.PloS one · 2015Trial
- Survival differences and artemisinin resistance in severe malaria among HIV coinfected patients: data from Mozambique.medRxiv : the preprint server for health sciences · 2026Article
- Observational
- Predictors of outcome in childhoodVirulence · 2020Review
- Article
- Malaria and HIV coinfection in sub-Saharan Africa: prevalence, impact, and treatment strategies.Research and reports in tropical medicine · 2018Review
- Single Domain Antibodies as New Biomarker Detectors.Diagnostics (Basel, Switzerland) · 2017Review
- Evidence for spleen dysfunction in malaria-HIV co-infection in a subset of pediatric patients.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- Article
- Simultaneous diagnosis of severe imported Plasmodium falciparum malaria and HIV: report of three cases.Malaria journal · 2015Article
- The pathogenesis of pediatric cerebral malaria: eye exams, autopsies, and neuroimaging.Annals of the New York Academy of Sciences · 2015Review
- Quality of inpatient pediatric case management for four leading causes of child mortality at six government-run Ugandan hospitals.PloS one · 2015Article
- Article
- Falciparum malaria as an emerging cause of fever in adults living in Gabon, Central Africa.BioMed research international · 2014Observational
- Article
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Authors and funding
15 authors at 7 institutions in 5 countries.
Funding
Abstract
backgroundSevere falciparum malaria with human immunodeficiency virus (HIV) coinfection is common in settings with a high prevalence of both diseases, but there is little information on whether HIV affects the clinical presentation and outcome of severe malaria.
methodsHIV status was assessed prospectively in hospitalized parasitemic adults and children with severe malaria in Beira, Mozambique, as part of a clinical trial comparing parenteral artesunate versus quinine (ISRCTN50258054). Clinical signs, comorbidity, complications, and disease outcome were compared according to HIV status.
resultsHIV-1 seroprevalence was 11% (74/655) in children under 15 years and 72% (49/68) in adults with severe malaria. Children with HIV coinfection presented with more severe acidosis, anemia, and respiratory distress, and higher peripheral blood parasitemia and plasma Plasmodium falciparum histidine-rich protein-2 (PfHRP2). During hospitalization, deterioration in coma score, convulsions, respiratory distress, and pneumonia were more common in HIV-coinfected children, and mortality was 26% (19/74) versus 9% (53/581) in uninfected children (P < .001). In an age- and antimalarial treatment-adjusted logistic regression model, significant, independent predictors for death were renal impairment, acidosis, parasitemia, and plasma PfHRP2 concentration.
conclusionsSevere malaria in HIV-coinfected patients presents with higher parasite burden, more complications, and comorbidity, and carries a higher case fatality rate. Early identification of HIV coinfection is important for the clinical management of severe malaria.
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