ArticleEuropean journal of nuclear medicine and molecular imaging2012
Left ventricular dyssynchrony assessed by gated SPECT phase analysis is an independent predictor of death in patients with advanced coronary artery disease and reduced left ventricular function not undergoing cardiac resynchronization therapy.
Article in European journal of nuclear medicine and molecular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Prognostic value of mechanical dyssynchrony in patients with heart failure: a systematic review.BMC cardiovascular disorders · 2024Pooled it
- Prognostic value of left ventricular mechanical dyssynchrony indices derived from gated myocardial perfusion SPECT in coronary artery disease: a systematic review and meta-analysis.Annals of nuclear medicine · 2024Pooled it
- The relationship of left ventricular mechanical dyssynchrony and cardiac sympathetic denervation to potential sudden cardiac death events in systolic heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Trial
- The Value of Stress-Gated Blood Pool SPECT in Predicting Early Postoperative Period Complications in Ischemic Cardiomyopathy Patients: Focus on Mechanical Dyssynchrony.Journal of clinical medicine · 2023Article
- Left ventricular mechanical dyssnchrony: A potential new marker for 3-vessel CAD.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prognostic Role of Diastolic Left Ventricular Mechanical Dyssynchrony by Gated Single Photon Emission Computed Tomography Myocardial Perfusion Imaging in Post-Myocardial Infarction.World journal of nuclear medicine · 2023Article
- Texture analysis of SPECT myocardial perfusion provides prognostic value for dilated cardiomyopathy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prediction of Cardiac Resynchronization Therapy Response Using Quantitative Gated Myocardial Perfusion Imaging.The Journal of innovations in cardiac rhythm management · 2023Article
- Myocardial scar reduction after cardiac resynchronization therapy assessed by gated myocardial perfusion SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Low-dose dobutamine stress gated blood pool SPECT assessment of left ventricular contractile reserve in ischemic cardiomyopathy: a feasibility study.European journal of nuclear medicine and molecular imaging · 2022Article
- Left ventricular mechanical dyssynchrony in patient with CAD: The Saga continues.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Prognostic Value of Phase Analysis for Predicting Adverse Cardiac Events Beyond Conventional Single-Photon Emission Computed Tomography Variables: Results From the REFINE SPECT Registry.Circulation. Cardiovascular imaging · 2021Observational
- Prognostic value of left ventricular mechanical dyssynchrony in hypertrophic cardiomyopathy patients with low risk of sudden cardiac death.Nuclear medicine communications · 2021Article
- Prognostic value of left ventricular mechanical dyssynchrony indices in long-standing type II diabetes mellitus with normal perfusion and left ventricular systolic functions on SPECT-MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Left ventricular mechanical dyssynchrony analzyed by Tc-99m sestamibi SPECT and F-18 FDG PET in patients with ischemic cardiomyopathy and the prognostic value.The international journal of cardiovascular imaging · 2020Article
- The prognostic value of diastolic and systolic mechanical left ventricular dyssynchrony among patients with coronary artery disease and heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Prognostic Value of Early Evaluation of Left Ventricular Dyssynchrony After Myocardial Infarction.Molecular imaging and biology · 2019Article
- Prognostic value of left ventricular dyssynchrony evaluated by gated myocardial perfusion imaging in patients with chronic kidney disease and normal perfusion defect scores.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Left ventricular phase entropy: Novel prognostic predictor in patients with dilated cardiomyopathy and narrow QRS.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Myocardial stunning-induced left ventricular dyssynchrony on gated single-photon emission computed tomography myocardial perfusion imaging.Nuclear medicine communications · 2018Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLeft ventricular (LV) mechanical dyssynchrony (LVMD) was assessed by gated single-photon emission CT myocardial perfusion imaging (MPI) as an independent predictor of death from any cause in patients with known coronary artery disease (CAD) and reduced LV function.
methodsBetween 2001 and 2010, 135 patients (64 ± 11 years of age, 84 % men) with known CAD, reduced LV ejection fraction (LVEF, 38 ± 15 %) and without an implanted cardiac resynchronization therapy device underwent gated MPI at rest. LV functional evaluation, which included phase analysis, was conducted to identify patients with LVMD. Kaplan-Meier survival curves were calculated for death of any cause during a mean follow-up of 2.0 ± 1.7 years. Uni- and multivariate Cox proportional hazards regression models were calculated to identify independent predictors of death from any cause.
resultsOf the 135 patients, 30 (22 %) died during follow-up (18 cardiac deaths and 12 deaths from other causes). Kaplan-Meier curves showed a significantly shorter survival time in the patients with severely reduced LVEF (<30 %, n = 45) or with LVMD (n = 81, log-rank test P <0.005). Cox models identified LVMD, LVEF < 30 % and a total perfusion deficit at rest of ≥ 20 % as independent predictors of death from any cause. While patients with LVEF <30 % in conjunction with LVMD had similar survival times irrespective of whether they had early revascularization or medical therapy, those patients with LVEF ≥ 30% and LVMD who underwent revascularization had significantly longer survival.
conclusionIn patients with known CAD and reduced LV function, dyssynchrony of the LV is an independent predictor of death from any cause.
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