ArticleClinical and experimental nephrology2013
Thrombotic microangiopathy and acute kidney injury following vivax malaria.
Article in Clinical and experimental nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical characteristics and outcome of malaria-associated acute kidney injury in adult patients: a systematic review and meta analysis.Malaria journal · 2026Pooled it
- Elevations in D-dimer levels in patients with Plasmodium infections: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Severe Plasmodium Falciparum Malaria Mimicking Thrombotic Thrombocytopenic Purpura (TTP): A Case Report From China.International medical case reports journal · 2025Article
- Plasmodium falciparum Malaria Presenting as a Thrombotic Thrombocytopenic Purpura (TTP) Mimic: A Case Report.Cureus · 2024Article
- Cutaneous manifestations of malaria.BMJ case reports · 2022Article
- Liver and kidney dysfunction, hypoglycemia, and thrombocytopenia inParasite epidemiology and control · 2021Article
- Malaria and acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2020Article
- Renal detection of Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi in malaria associated acute kidney injury: a retrospective case-control study.BMC research notes · 2020Article
- Hemolytic uremic syndrome in a developing country: Consensus guidelines.Pediatric nephrology (Berlin, Germany) · 2019Article
- Etiology and Outcomes of Thrombotic Microangiopathies.Clinical journal of the American Society of Nephrology : CJASN · 2019Article
- Distinct inflammatory profile underlies pathological increases in creatinine levels associated with Plasmodium vivax malaria clinical severity.PLoS neglected tropical diseases · 2018Article
- Acute kidney injury induced by thrombotic microangiopathy in a patient with hemophagocytic lymphohistiocytosis.BMC nephrology · 2016Article
- Podocyte and endothelial injury in focal segmental glomerulosclerosis: an ultrastructural analysis.Virchows Archiv : an international journal of pathology · 2015Article
- Parasite biomass-related inflammation, endothelial activation, microvascular dysfunction and disease severity in vivax malaria.PLoS pathogens · 2015Article
- Malaria-induced splenic infarction.The American journal of tropical medicine and hygiene · 2014Article
- Hemolytic uremic syndrome associated with Plasmodium vivax malaria successfully treated with plasma exchange.Indian journal of nephrology · 2014Article
- Postrenal transplant Plasmodium vivax malaria: neglected and not benign.Parasitology research · 2013Article
- Distinct renal pathology and a chemotactic phenotype after enterohemorrhagic Escherichia coli shiga toxins in non-human primate models of hemolytic uremic syndrome.The American journal of pathology · 2013Article
- Evidence and implications of mortality associated with acute Plasmodium vivax malaria.Clinical microbiology reviews · 2013Review
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10 authors.
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Abstract
backgroundInfection with Plasmodium vivax, a common human parasite, is occasionally recognized to cause severe organ dysfunction similar to P. falciparum infection. Acute kidney injury (AKI) in malaria is attributed to acute tubular necrosis; thrombotic microangiopathy is not described.
methodsThis observational study includes patients referred to a tertiary care center in North India during June to September 2011 with severe AKI, anemia, and thrombocytopenia following vivax malaria. Renal biopsies were processed by light, immunofluorescence, and electron microscopy.
resultsNine patients (including 5 children) had persistent AKI with thrombocytopenia and variable anemia following the diagnosis of malaria. Based on peripheral smear, eight patients were diagnosed with vivax malaria and had received antimalarial therapy prior to referral; a laboratory diagnosis of P. vivax infection was made for one patient at this center. Renal histology in all cases showed features of thrombotic microangiopathy, including fibrin thrombi, subendothelial widening, and mesangiolysis, along with variable tubulointerstitial nephritis and acute tubular or cortical necrosis. Ultrastructural examination confirmed endothelial injury and subendothelial widening. All patients required hemodialysis, and six were dialysis dependent at four weeks. Delayed presentation to the hospital (P = 0.019), hemolysis on peripheral smear (P = 0.083), and prolonged oligoanuria (P = 0.036) were associated with dialysis dependence.
conclusionThe association of anemia, thrombocytopenia, and renal histological evidence of thrombotic microangiopathy with vivax malaria is novel, and suggests the presence of severe endothelial injury. Further studies are necessary to confirm the association and examine the factors associated with its occurrence.
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