Trial reportIntensive care medicine2012
Effects of propofol on sleep quality in mechanically ventilated critically ill patients: a physiological study.
Trial report in Intensive care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04204798 (Impact of Low-dose Dexmedetomidine on Outcomes of Elderly Admitted to ICU After Noncardiac Surgery), which is not on this map. Cited by 50 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Low-dose Dexmedetomidine on Outcomes of Elderly Admitted to ICU After Noncardiac Surgery: a Randomized Controlled Trial
Who cites it
50 citing papers in PubMed, 5 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Remimazolam vs propofol for postoperative delirium in adults undergoing general anesthesia: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- A Systematic Review of Sleep Measurement in Critically Ill Patients.Frontiers in neurology · 2020Pooled it
- Propofol for the promotion of sleep in adults in the intensive care unit.The Cochrane database of systematic reviews · 2018Pooled it
- Pharmacological interventions to improve sleep in hospitalised adults: a systematic review.BMJ open · 2016Pooled it
- A meta-analysis of sleep-promoting interventions during critical illness.The American journal of medicine · 2015Pooled it
- Repeated remimazolam sedation for interstitial brachytherapy in cervical cancer: a randomized controlled trial.Annals of medicine · 2026Trial
- Effect of the orexin receptor antagonist, suvorexant, on sleep architecture in the early postoperative period following cardiac surgery: a randomized controlled trial.Critical care (London, England) · 2026Trial
- Comparison of Intraoperative Noise Isolation and White Noise on Postoperative Sleep in Patients Undergoing Flexible Ureteroscopic Holmium: YAG Laser Lithotripsy: A Randomized Clinical Trial.Nature and science of sleep · 2026Trial
- The Impact of Anesthetic Management Under Bispectral Index Monitoring on the Early Recovery Quality of Elderly Patients Undergoing Laparoscopic Surgery: A Blinded Randomized Controlled Trial.Clinical interventions in aging · 2025Trial
- Sleep quality and quantity determined by polysomnography in mechanically ventilated critically ill patients randomized to dexmedetomidine or placebo.Acta anaesthesiologica Scandinavica · 2023Trial
- Trial
- Effect of oral melatonin and wearing earplugs and eye masks on nocturnal sleep in healthy subjects in a simulated intensive care unit environment: which might be a more promising strategy for ICU sleep deprivation?Critical care (London, England) · 2015Trial
- Trial
- Patient-ventilator synchrony and sleep quality with proportional assist and pressure support ventilation.Intensive care medicine · 2013Trial
- Breaking the Limitations of 'Milk': Research Progress on New Derivatives of Propofol.Molecules (Basel, Switzerland) · 2026Review
- Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus.Annals of clinical and translational neurology · 2026Article
- The effect of remimazolam and propofol on post-hysteroscopy sleep quality under general anesthesia: aFrontiers in pharmacology · 2025Article
- Effect of sleep quality on weaning from mechanical ventilation: A scoping review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Review
- Effect of prolonged sedation with dexmedetomidine, midazolam, propofol, and sevoflurane on sleep homeostasis in rats.British journal of anaesthesia · 2024Article
- A Comparison of Efficacy between Low-dose Dexmedetomidine and Propofol for Prophylaxis of Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Surgery: A Randomized Controlled Trial.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo access the effect of propofol administration on sleep quality in critically ill patients ventilated on assisted modes.
methodsThis was a randomized crossover physiological study conducted in an adult ICU at a tertiary hospital. Two nights' polysomnography was performed in mechanically ventilated critically ill patients with and without propofol infusion, while respiratory variables were continuously recorded. Arterial blood gasses were measured in the beginning and at the end of the study. The rate of propofol infusion was adjusted to maintain a sedation level of 3 on the Ramsay scale. Sleep architecture was analyzed manually using predetermined criteria. Patient-ventilator asynchrony was evaluated breath by breath using the flow-time and airway pressure-time waveforms.
resultsTwelve patients were studied. Respiratory variables, patient-ventilator asynchrony, and arterial blood gasses did not differ between experimental conditions. With or without propofol all patients demonstrated abnormal sleep architecture, expressed by lack of sequential progression through sleep stages and their abnormal distribution. Sleep efficiency, sleep fragmentation, and sleep stage distribution (1, 2, and slow wave) did not differ with or without propofol. Compared to without propofol, both the number of patients exhibiting REM sleep (p = 0.02) and the percentage of REM sleep (p = 0.04) decreased significantly with propofol.
conclusionsIn critically ill patients ventilated on assisted modes, propofol administration to achieve the recommended level of sedation suppresses the REM sleep stage and further worsens the poor sleep quality of these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.