Evidence map›Paper›PMID 22752310›Full record

ArticleJournal of clinical immunology2012

Acidomonas methanolica-associated necrotizing lymphadenitis in a patient with chronic granulomatous disease.

John M Chase, Steven M Holland, David E Greenberg, Kimberly Marshall-Batty, Adrian M Zelazny, Joseph A Church

Abstract readCase Reports
In one paragraph

Article in Journal of clinical immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. NADPH Oxidase Deficiency: A Multisystem Approach.Oxidative medicine and cellular longevity · 2017
    Review
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

John M ChaseDivision of General Pediatrics, MS#75, Children's Hospital Los Angeles and Keck School of Medicine, University of Southern California, 4650 Sunset Blvd., Los Angeles, CA 90027, USA. chasejm@gmail.com
Steven M Holland
David E Greenberg
Kimberly Marshall-Batty
Adrian M Zelazny
Joseph A Church
National Institute of Allergy and Infectious Diseases · USChildren's Hospital of Los Angeles · USThe University of Texas Southwestern Medical Center · USUniversity of Southern California · US

Funding

Transgenic Animal Models Of Human Immune DefectsZIAAI000646 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.2M
TRANSGENIC ANIMAL MODELS OF HUMAN IMMUNE DEFECTSZ01AI000646 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI HOLLAND, STEVEN M · 1992 to 2008
$2.4M
Identification of Clinically Important Microbes by Genomic and Proteomic MethodsZIACL080012 · CLC · CLINICAL CENTER · PI ZELAZNY, ADRIAN MARCELO · 2009 to 2025
$0k
Intramural NIH HHS Z01 AI000646
6 · The paper itself

Abstract

purposeAdenitis for which no causative organism can be isolated is a common occurrence in patients with chronic granulomatous disease (CGD). Here we identify Acidomonas methanolica as a pathogen associated with adenitis in a patient with CGD.

methodsThe causative pathogen was obtained after prolonged incubation of an excised lymph node in thioglycolate broth. Identification was carried out by sequencing the 16s rRNA. Immunoblots were prepared utilizing protein extracts from the case patient's A. methanolica isolate, an ATCC type strain of A. methanolica and G. bethesdensis.

resultsFastidious gram-negative rods grew after prolonged incubation of an excised lymph node in thioglycolate broth. Sequencing of the 16s rRNA identified the organism as A. methanolica. Immunoblot confirmed the pathogen's role in the patient's adenitis by showing the patient's specific immune response to the organism.

conclusionsA. methanolica is the second member of the family, Acetobacteaceae to be associated with adenitis in patients with CGD.

Indexed as

AcetobacteraceaeChildGranulomatous Disease, ChronicHistiocytic Necrotizing LymphadenitisHumansLymph NodesMaleRNA, Ribosomal, 16SRNA, Ribosomal, 16S

Identifiers

PMID22752310
PMCPMC4103907
OpenAlexW2001290994

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.