ArticleJournal of molecular evolution2012
Mutational bias plays an important role in shaping longevity-related amino acid content in mammalian mtDNA-encoded proteins.
Article in Journal of molecular evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The Role of Amino Acids in Non-Enzymatic Antioxidant Mechanisms in Cancer: A Review.Metabolites · 2023Review
- Methionine in proteins: The Cinderella of the proteinogenic amino acids.Protein science : a publication of the Protein Society · 2019Review
- In Cold Blood: Compositional Bias and Positive Selection Drive the High Evolutionary Rate of Vampire Bats Mitochondrial Genomes.Genome biology and evolution · 2018Article
- Sulphur Atoms from Methionines Interacting with Aromatic Residues Are Less Prone to Oxidation.Scientific reports · 2015Article
- A description of the complete mitochondrial genomes of Amphiporus formidabilis, Prosadenoporus spectaculum and Nipponnemertes punctatula (Nemertea: Hoplonemertea: Monostilifera).Molecular biology reports · 2014Article
- Life-history Constraints on the Mechanisms that Control the Rate of ROS Production.Current genomics · 2014Article
- Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii.Nature communications · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
During the course of evolution, amino acid shifts might have resulted in mitochondrial proteomes better endowed to resist oxidative stress. However, owing to the problem of distinguishing between functional constraints/adaptations in protein sequences and mutation-driven biases in the composition of these sequences, the adaptive value of such amino acid shifts remains under discussion. We have analyzed the coding sequences of mtDNA from 173 mammalian species, dissecting the effect of nucleotide composition on amino acid usages. We found remarkable cysteine avoidance in mtDNA-encoded proteins. However, no effect of longevity on cysteine content could be detected. On the other hand, nucleotide compositional shifts fully accounted for threonine usages. In spite of a strong effect of mutational bias on methionine abundances, our results suggest a role of selection in determining the composition of methionine. Whether this selective effect is linked or not to protection against oxidative stress is still a subject of debate.
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Registered trials
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