Evidence map›Paper›PMID 22751537›Full record

ArticleAntimicrobial agents and chemotherapy2012

Serotype and clonal evolution of penicillin-nonsusceptible invasive Streptococcus pneumoniae in the 7-valent pneumococcal conjugate vaccine era in Italy.

Giovanni Gherardi, Fabio D'Ambrosio, Daniela Visaggio, Giordano Dicuonzo, Maria Del Grosso, Annalisa Pantosti

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Genomic characterization ofMicrobial genomics · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Homology analysis of 51 penicillin-intermediateThe Journal of international medical research · 2020
    Article
  6. Vaccination can drive an increase in frequencies of antibiotic resistance among nonvaccine serotypes ofProceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Mechanisms of genome evolution of Streptococcus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015
    Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Giovanni GherardiCentro Integrato di Ricerche, Laboratory of Microbiology, Università Campus Biomedico, Rome, Italy.
Fabio D'Ambrosio
Daniela Visaggio
Giordano Dicuonzo
Maria Del Grosso
Annalisa Pantosti
Istituto Superiore di Sanità · ITUniversità Campus Bio-Medico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The percentage of invasive penicillin-nonsusceptible pneumococci (PNSSP) isolated in Italy in the seven-valent pneumococcal conjugate vaccine (PCV7) era moderately increased in comparison to the pre-PCV7 era. Increase of nonvaccine serotypes was observed among PNSSP. The most frequent PNSSP clones were the same as those identified in the pre-PCV7 era, although they were present in different proportions. Clonal expansion, emergence of new clones, and acquisition of penicillin resistance by established clones contributed to the maintenance of penicillin resistance.

Indexed as

Anti-Bacterial AgentsClonal EvolutionClone CellsHumansItalyPenicillin ResistancePenicillinsPneumococcal InfectionsPneumococcal VaccinesSerotypingStreptococcus pneumoniaeVaccines, ConjugateAnti-Bacterial AgentsPenicillinsPneumococcal VaccinesVaccines, Conjugate

Identifiers

PMID22751537
PMCPMC3421861
OpenAlexW2049379722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.