ArticleGenes & development2012
Growth phase-dependent control of transcription start site selection and gene expression by nanoRNAs.
Article in Genes & development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 47 citations in OpenAlex.
- Molecular insight into 5' RNA capping with NpNature chemical biology · 2026Article
- The displacement of the σ70 finger in initial transcription is highly heterogeneous and promoter-dependent.Nucleic acids research · 2025Article
- Understanding the impact ofFrontiers in molecular biosciences · 2024Review
- Nano-RNases: oligo- or dinucleases?FEMS microbiology reviews · 2022Review
- Step-by-Step Regulation of Productive and Abortive Transcription Initiation by Pyrophosphorolysis.Journal of molecular biology · 2022Article
- Article
- RNA polymerase spoiled for choice as transcription begins.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Promoter-sequence determinants and structural basis of primer-dependent transcription initiation inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Use of NAD tagSeq II to identify growth phase-dependent alterations inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Regulation of mRNA Stability During Bacterial Stress Responses.Frontiers in microbiology · 2020Review
- Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.Molecular cell · 2019Article
- A dedicated diribonucleotidase resolves a key bottleneck for the terminal step of RNA degradation.eLife · 2019Article
- Region 3.2 of the σ factor controls the stability of rRNA promoter complexes and potentiates their repression by DksA.Nucleic acids research · 2018Article
- Epitranscriptomics: RNA Modifications in Bacteria and Archaea.Microbiology spectrum · 2018Article
- Analysis of Bacterial Transcription by "Massively Systematic Transcript End Readout," MASTER.Methods in enzymology · 2018Article
- Structural Basis for the Bidirectional Activity of Bacillus nanoRNase NrnA.Scientific reports · 2017Article
- Open complex DNA scrunching: A key to transcription start site selection and promoter escape.BioEssays : news and reviews in molecular, cellular and developmental biology · 2017Review
- Interactions between RNA polymerase and the core recognition element are a determinant of transcription start site selection.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- tRNAs taking charge.Pathogens and disease · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Prokaryotic and eukaryotic RNA polymerases can use 2- to ∼4-nt RNAs, "nanoRNAs," to prime transcription initiation in vitro. It has been proposed that nanoRNA-mediated priming of transcription can likewise occur under physiological conditions in vivo and influence transcription start site selection and gene expression. However, no direct evidence of such regulation has been presented. Here we demonstrate in Escherichia coli that nanoRNAs prime transcription in a growth phase-dependent manner, resulting in alterations in transcription start site selection and changes in gene expression. We further define a sequence element that determines, in part, whether a promoter will be targeted by nanoRNA-mediated priming. By establishing that a significant fraction of transcription initiation is primed in living cells, our findings contradict the conventional model that all cellular transcription is initiated using nucleoside triphosphates (NTPs) only. In addition, our findings identify nanoRNAs as a previously undocumented class of regulatory small RNAs that function by being directly incorporated into a target transcript.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.