ArticleMolecular psychiatry2013
Family-based study of HTR2A in suicide attempts: observed gene, gene × environment and parent-of-origin associations.
Article in Molecular psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Association of the 5HTR2A gene with suicidal behavior: case-control study and updated meta-analysis.BMC psychiatry · 2013Pooled it
- Biological Basis for the Formation of Suicidal Behavior: A Review.Medical journal of the Islamic Republic of Iran · 2025Review
- Mood disorders and 5-HTR2A genetic variants - the moderator effect of inflammation on expression of affective polarity phenotype.BMC psychiatry · 2024Article
- Interaction between HTR2A rs3125 and negative life events in suicide attempts among patients with major depressive disorder: a cross-sectional study.BMC psychiatry · 2024Article
- Peer victimization, depression, and non-suicidal self-injury among Chinese adolescents: the moderating role of the 5-HTR2A gene rs6313 polymorphism.Child and adolescent psychiatry and mental health · 2022Article
- The Implication of 5-HT Receptor Family Members in Aggression, Depression and Suicide: Similarity and Difference.International journal of molecular sciences · 2022Review
- AVPR1A main effect and OXTR-by-environment interplay in individual differences in depression level.Heliyon · 2020Article
- Epigenetics and Depression: An Update.Psychiatry investigation · 2019Article
- Association of rs4680Frontiers in psychiatry · 2019Article
- 5-HTNeurobiology of stress · 2017Article
- Precision medicine for suicidality: from universality to subtypes and personalization.Molecular psychiatry · 2017Article
- Understanding Suicide Risk within the Research Domain Criteria (RDoC) Framework: Insights, Challenges, and Future Research Considerations.Clinical psychological science : a journal of the Association for Psychological Science · 2017Article
- Polygenic associations of neurodevelopmental genes in suicide attempt.Molecular psychiatry · 2016Article
- Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future Directions.Frontiers in psychiatry · 2016Review
- Article
- 5-HT2A Gene Variants Moderate the Association between PTSD and Reduced Default Mode Network Connectivity.Frontiers in neuroscience · 2016Article
- Predictors of suicide attempts in 3.322 patients with affective disorders and schizophrenia spectrum disorders.Psychiatry research · 2015Article
- Investigating the role of early childhood abuse and HPA axis genes in suicide attempters with bipolar disorder.Psychiatric genetics · 2015Article
- Polymorphism in the serotonin receptor 2a (HTR2A) gene as possible predisposal factor for aggressive traits.PloS one · 2015Article
- Meta-analysis: a tool for clinical and experimental research in psychiatry.Nordic journal of psychiatry · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While suicidal behavior is frequently accompanied by serotonergic system alterations, specific associations with genetic variation in the serotonin 2A receptor (HTR2A) gene have been inconsistent. Using a family-based study design of 660 offspring who have made a suicide attempt (SA) and both parents, we conducted an association and linkage analysis using single-nucleotide polymorphisms (SNPs) with extensive gene coverage, and included the study of parent-of-origin (POE) and gene-environment interaction (G × E), also using previously unstudied exposures. The main finding was a G × E between the exon 1 SNP rs6313 and exposure to cumulative types of lifetime stressful life events (SLEs), driven by overtransmission of CT and undertransmission of TT, both in relation to other genotypes. Further exploratory analysis revealed a significant POE in this G × E in female subjects, which followed a polar overdominant inheritance pattern. In addition, rs6310 and rs6305 were found to significantly associate with SA in the total sample. A G × E in female subjects (rs7322347 × physical assault in childhood/adolescence) confirmed features of a previously observed association with SA. Other potentially interesting nominally significant findings were observed, but like the G × E of rs7322347 did not pass a false-discovery rate cutoff. Taken together, this study found multiple associations of HTR2A SNPs on SA, with strongest statistical evidence for a G × E involving rs6313, and further suggested the importance of taking into account different inheritance patterns and G × Es with regard to HTR2A.
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