Trial reportOncology nursing forum2012
Assessing agreement between salivary alpha amylase levels collected by passive drool and eluted filter paper in adolescents with cancer.
Trial report in Oncology nursing forum, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Salivary alpha-amylase: A marker of stress in gynecological residents during a shoulder dystocia simulation scenario.PloS one · 2024Article
- Comparison of biomarkers in blood and saliva in healthy adults.Nursing research and practice · 2012Article
- Exploring Inflammation and Stress as Biological Correlates of Symptoms in Children With Advanced Cancer: A Longitudinal Feasibility Study.Journal of pediatric hematology/oncology nursingArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
PURPOSE/
objectivesTo assess the validity of filter paper (FP) against the gold standard of passive drool (PD) for collecting salivary alpha amylase as a surrogate biomarker of psychological stress in adolescents with cancer.
designPart of a longitudinal, descriptive study of symptoms in adolescents with cancer during chemotherapy.
settingA pediatric hematology/oncology treatment center. SAMPLE: 33 saliva sample pairs from nine adolescents with cancer, aged 13-18 years.
methodsSalivary alpha amylase was collected by PD and FP at four time points during a cycle of chemotherapy: days 1 (time 1) and 2 (time 2) of chemotherapy, day 7-10 (time 3), and day 1 of the next cycle (time 4). A random effects regression was used to assess the correlation between PD and FP values, and a Bland Altman analysis was conducted to assess agreement between the values. MAIN RESEARCH VARIABLES: Salivary alpha amylase.
findingsThe estimated correlation between PD and FP values was r = 0.91, p < 0.001. Regression results were also used to rescale FP values to the levels of the PD values because the FP values were on a different scale than the PD values. The Bland Altman analysis revealed that the agreement between the rescaled FP values and PD values was not satisfactory.
conclusionsEluted FP may not be a valid method for collecting salivary alpha amylase in adolescents with cancer. IMPLICATIONS FOR NURSING: Psychological stress in adolescents with cancer may be linked to negative outcomes, such as greater symptom severity and post-traumatic stress disorder. Nurses need valid, efficient, biobehavioral measures to assess psychological stress in the clinical setting.
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